The cyanobacterial clock and metabolism.
The cyanobacterial clock and metabolism.
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DOI：
10.1016/j.mib.2014.02.010
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发表时间：
2014-04
影响因子：
5.4
通讯作者：
Rust MJ
中科院分区：
文献类型：
--
作者：
Pattanayak G;Rust MJ
蓝细菌拥有已知最简单的生物钟，这为研究节奏如何产生以及来自环境的输入信号如何重置时钟时间提供了一个独特的机会。kaiABC基因座形成了振荡器的核心，使用纯化的KaiABC蛋白重建振荡的显着能力使研究人员能够使用定量生物化学工具研究机制。自养蓝藻经历了重大的转变，代谢后的光暗过渡，最近的工作表明，输入机制，耦合昼夜周期的时钟涉及能量和氧化还原代谢产物直接作用于时钟蛋白。我们提供了一个总结，在这个系统中的知识的现状，并提出了未来的调查线的角度。
Cyanobacteria possess the simplest known circadian clock, which presents a unique opportunity to study how rhythms are generated and how input signals from the environment reset the clock time. The kaiABC locus forms the core of the oscillator, and the remarkable ability to reconstitute oscillations using purified KaiABC proteins has allowed researchers to study mechanism using the tools of quantitative biochemistry. Autotrophic cyanobacteria experience major shifts in metabolism following a light-dark transition, and recent work suggests that input mechanisms that couple the day-night cycle to the clock involve energy and redox metabolites acting directly on clock proteins. We offer a summary of the current state of knowledge in this system and present a perspective for future lines of investigation.