The effect of endometrial thickness on IVF/ICSI outcome
The effect of endometrial thickness on IVF/ICSI outcome
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DOI：
10.1093/humrep/deg461
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发表时间：
2003-11-01
影响因子：
6.1
通讯作者：
Kaali, SG
中科院分区：
文献类型：
--
作者：
Kovacs, P;Matyas, S;Kaali, SG
背景：在月经周期中，子宫内膜经历周期性的增殖和分泌变化，为着床做准备。如果这种准备不充分，那么植入将失败。本研究探讨了胚胎移植当天子宫内膜厚度对IVF结局的影响。方法：回顾性分析1228个IVF/ICSI周期的临床资料。三分之一的周期用克罗米芬（CC）+ hMG刺激，三分之二的周期用超短GnRH激动剂刺激。比较妊娠和非妊娠患者的周期参数。对正在进行的怀孕和导致流产的怀孕进行了类似的比较。结果如下：辅助生殖后妊娠妇女的卵泡、卵母细胞和胚胎数量均多于未妊娠妇女，子宫内膜较厚，胚胎质量较高。妊娠率随子宫内膜厚度增加而提高。在持续妊娠和导致早期妊娠丢失的妊娠之间，没有发现周期参数和子宫内膜厚度的差异。CC对子宫内膜无明显不良影响，但CC+hMG周期妊娠率较低。结论：子宫内膜厚度增加与较高的妊娠率有关。然而，无论是实现妊娠或妊娠结局预测子宫内膜厚度单独。
Background: During the menstrual cycle the endometrium undergoes cyclic proliferative and secretory changes in preparation for implantation. If this preparation is not sufficient, then implantation will fail. The impact of endometrial thickness on the day of embryo transfer on IVF outcome was investigated in the present study. Methods: A retrospective analysis was conducted of 1228 IVF/ICSI cycles. Stimulation was with clomiphene citrate (CC) + hMG in one-third of the cycles, and ultrashort GnRH agonist stimulation in two-thirds. Cycle parameters were compared between pregnant and non-pregnant patients. A similar comparison was made between ongoing pregnancies and those that resulted in a loss. Results: There were more follicles, oocytes and embryos, the endometrium was thicker and the embryo quality was higher among women who became pregnant when compared with non-pregnant women after assisted reproduction. The pregnancy rate improved as endometrial thickness increased. No difference in cycle parameters and endometrial thickness was found between ongoing pregnancies and pregnancies that resulted in a first-trimester loss. CC had no measurable adverse endometrial effect, but the pregnancy rate was lower in CC+hMG cycles. Conclusions: Increased endometrial thickness is associated with higher pregnancy rates. However, neither attainment of pregnancy nor pregnancy outcome was predicted by endometrial thickness alone.