INHIBITION OF STREPTOLYSIN-S BY THE SERUM OF PATIENTS WITH RHEUMATIC FEVER AND ACUTE STREPTOCOCCAL PHARYNGITIS
INHIBITION OF STREPTOLYSIN-S BY THE SERUM OF PATIENTS WITH RHEUMATIC FEVER AND ACUTE STREPTOCOCCAL PHARYNGITIS
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DOI：
10.1172/jci102352
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发表时间：
1950-01-01
影响因子：
15.9
通讯作者：
BERNHEIMER, AW
中科院分区：
文献类型：
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作者：
STOLLERMAN, GH;BERNHEIMER, AW
测定正常人和风湿热、链球菌性咽炎及其他疾病患者血清中溶血素S （a群链球菌产生的溶血素）的抑制能力。80%的急性风湿热患者在严重的风湿病活动期间血清溶血素S抑制剂水平下降到正常值以下，在恢复期恢复到正常水平。在一些不相关的疾病中也会出现低溶血素S抑制剂滴度，因此，这种下降似乎不是风湿热所特有的。A群链球菌引起的急性咽炎患者滴度无变化。在风湿热患者中，溶血素S抑制剂没有升高，而在相同的血清中，抗溶血素O和抗链激酶滴度明显升高。从急性咽炎患者和风湿热患者的喉咙中分离出的23株A群链球菌在体外显示能够产生溶血素S。这些发现表明，溶血素S在人体内不具有抗原性，血清抑制溶血素S的能力是由于血清的正常成分而不是特异性抗体。本文讨论了溶血性链球菌素S抑制剂的性质及其在风湿热中降低的意义。
The sera of normal subjects and patients with rheumatic fever, streptococcal pharyngitis and miscellaneous diseases were titrated for their capacity to inhibit streptolysin S, a hemolysin produced by Group A streptococci. 80% of patients with acute rheumatic fever showed a fall in the serum level of streptolysin S inhibitor below normal values during severe rheumatic activity and a return to normal levels during convalescence. A low streptolysin S inhibitor titer was also encountered in some cases of unrelated diseases and the fall, therefore, does not appear to be specific for rheumatic fever. Patients with acute pharyngitis due to Group A streptococci showed no change in titer. In patients with rheumatic fever there was no elevation in streptolysin S inhibitor in contrast to the marked rise in antistreptolysin O and antistreptokinase titers measured on the same sera. 23 strains of Group A streptococci isolated from the throats of patients with acute pharyngitis and from those with rheumatic fever were shown to be capable of producing streptolysin S in vitro. These findings indicate that streptolysin S is not antigenic in man and that the capacity of serum to inhibit streptolysin S is due to a normal component of serum rather than to a specific antibody. The nature of the streptolysin S inhibitor and the significance of its decrease in rheumatic fever are discussed.