Efficient Nef-Mediated Downmodulation of TCR-CD3 and CD28 Is Associated with High CD4+ T Cell Counts in Viremic HIV-2 Infection
Efficient Nef-Mediated Downmodulation of TCR-CD3 and CD28 Is Associated with High CD4+ T Cell Counts in Viremic HIV-2 Infection
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DOI：
10.1128/jvi.06856-11
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发表时间：
2012-05-01
影响因子：
5.4
通讯作者：
Kirchhoff, Frank
中科院分区：
文献类型：
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作者：
Khalid, Mohammad;Yu, Hangxing;Kirchhoff, Frank
多功能辅助Nef蛋白在HIV-2感染的免疫发病机制中的作用目前尚不清楚。在这里，我们对来自21个病毒血症（血浆病毒载量，bbb50拷贝/ml）和16个非病毒血症（血浆病毒载量，500copies /ml）的50个nef基因进行了综合功能分析。
The role of the multifunctional accessory Nef protein in the immunopathogenesis of HIV-2 infection is currently poorly understood. Here, we performed comprehensive functional analyses of 50 nef genes from 21 viremic (plasma viral load, > 500 copies/ml) and 16 nonviremic (