C-reactive protein level and risk of aging macula disorder - The Rotterdam study
C-reactive protein level and risk of aging macula disorder - The Rotterdam study
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DOI：
10.1001/archopht.125.10.1396
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发表时间：
2007-10-01
影响因子：
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通讯作者：
de Jong, Paulus T. V. M.
中科院分区：
文献类型：
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作者：
Boekhoorn, Sharmila S.;Vingerling, Johannes R.;de Jong, Paulus T. V. M.
目的：探讨C反应蛋白（CRP）水平在普通人群中是否为老年性黄斑病变（AMD）的危险因素。方法：我们在以人群为基础的鹿特丹研究中检测了4914名有AMD风险的参与者的血清高敏CRP （HsCRP）水平。平均随访7.7年，发现早期AMD 561例，晚期AMD 97例。我们使用Cox比例风险回归模型来估计风险比和相应的95%置信区间（ci）。结果：调整年龄和性别后，早期iAMD的HsCRP水平每标准差增加的风险比为1.11 (95% CI, 1.02- 1.21)，晚期iAMD的风险比为1.28 （95% CI, 1.02- 1.60）。HsCRP水平每增加四分位数，早期iAMD的风险比增加如下：第二个四分位数，1.19 (95% CI, 0.94- 1.52)；第三个四分位数，1.29 (95% CI, 1.01- 1.64)；第四分位数为1.33 （95% CI, 1.05- 1.70）。晚期iAMD的风险在所有HsCRP的上四分位数中都较高。结论：在这个以人群为基础的队列中，HsCRP基线水平升高与早期和晚期AMD的发展有关。
Objective: To examine whether C- reactive protein ( CRP) level is a risk factor for aging macula disorder ( AMD) in a general population.Methods: We examined serum high- sensitivity CRP ( HsCRP) levels in 4914 participants of the population-based Rotterdam Study at risk for AMD. After a mean follow-up of 7.7 years, 561 cases of early and 97 cases of late incident AMD( iAMD) were identified. We used Cox proportional hazards regression models to estimate hazard ratios and corresponding 95% confidence intervals ( CIs).Results: After adjustment for age and sex, hazard ratios were 1.11 ( 95% CI, 1.02- 1.21) per standard deviation increase in HsCRP level for early iAMD and 1.28 ( 95% CI, 1.02- 1.60) for late iAMD. Hazard ratios for early iAMD increased per quartile increase in HsCRP level as follows: second quartile, 1.19 ( 95% CI, 0.94- 1.52); third quartile, 1.29 ( 95% CI, 1.01- 1.64); and fourth quartile, 1.33 ( 95% CI, 1.05- 1.70). The risk of late iAMD was higher in all upper quartiles of HsCRP.Conclusion: Elevated baseline levels of HsCRP were associated with the development of early and late AMD in this large population- based cohort.