Identifying functional links between genes using conserved chromosomal proximity
Identifying functional links between genes using conserved chromosomal proximity
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DOI：
10.1016/s0168-9525(01)02621-x
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发表时间：
2002-04-01
影响因子：
11.4
通讯作者：
DeLisi, C
中科院分区：
文献类型：
--
作者：
Yanai, I;Mellor, JC;DeLisi, C
一对基因在多个基因组中的接近程度保持不变，通常表明它们的功能可能是相连的。在这里，我们使用来自25个系统发育类群的42个完整的微生物基因组进行了系统的评估，以测试这一观察结果在预测基因功能方面的可靠性。我们发现了基因对接近的系统发育群的数量与该基因对属于共同路径的概率之间的关系。我们的方法在直系同源家族之间产生了1586个链接，通过观察到代表至少三个系统发育组的基因组中的接近而得到证实。在KEGG数据库中标注的对中，80%在KEGG中处于相同的生物途径中。
Conservation of proximity of a pair of genes across multiple genomes generally indicates that their functions could be linked. Here, we present a systematic evaluation using 42 complete microbial genomes from 25 phylogenetic groups to test the reliability of this observation in predicting function for genes. We find a relationship between the number of phylogenetic groups in which a gene pair is proximate and the probability that the pair belongs to a common pathway. Our method produces 1586 links between ortholog families substantiated by observed proximity in genomes representing at least three phylogenetic groups. Of the pairs annotated in the KEGG database, 80% are in the same biological pathway in KEGG.