Autonomic nervous functions in fetal type Minamata disease patients: Assessment of heart rate variability
Autonomic nervous functions in fetal type Minamata disease patients: Assessment of heart rate variability
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DOI：
10.1620/tjem.198.215
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发表时间：
2002-12-01
影响因子：
2.2
通讯作者：
Futatsuka, M
中科院分区：
文献类型：
--
作者：
Oka, T;Matsukura, M;Futatsuka, M
为了评估胎儿型水俣病（FMD）患者的心血管自主神经功能，我们测量了血压（BP），并对心率变异性（HRV）进行了时频域分析。研究对象为梅睢县确诊口蹄疫患者9例，健康年龄匹配对照13例。在受试者仰卧10分钟后评估HRV和血压。在自然呼吸状态下采集3分钟的心电图数据。然后进行时域分析（R-R区间的平均值[Mean RR]、R-R区间的标准差[SD RR]、变异系数[CV]）和快速傅立叶变换（FFT）频域分析（低频[LF]和高频[HF]分量的功率，以归一化单位[nu]表示）。在时域分析中，FMD组的平均RR显著低于对照组。两组间SD RR和CV均无显著差异，但FMD组均有降低的趋势。频域分析中，口蹄疫组的HF分量显著低于对照组。FMD患者的脉压（PP）明显降低。这些发现表明，在产前暴露于高剂量甲基汞（MeHg）的FMD患者可能存在副交感神经功能障碍。PP的减少可能是由于暴露于高剂量甲基汞引起的血管退行性改变。-胎儿型水俣病；自主神经功能；心率变异性；甲基汞(C) 2002东北大学医学出版社。
In order to assess the cardiovascular autonomic nervous functions in patients with fetal type Minamata disease (FMD), we investigated blood pressure (BP), and conducted time and frequency domain analysis of heart rate variability (HRV). Subjects were 9 patients in Meisuien recognized as FMD, and 13 healthy age matched control subjects. HRV and BP were assessed after subjects rested in a supine position for 10 minutes. Electrocardiographic (ECG) data were collected for 3 minutes during natural breathing. Time domain analysis (the average of R-R intervals [Mean RR], standard deviation of R-R intervals [SD RR], coefficient of variation [CV]), and frequency domain analysis by fast Fourier transformation (FFT) (power of low frequency [LF] and high frequency [HF] component, expressed in normalized units[nu]) were then conducted. In the time domain analysis, the mean RR of the FMD group was significantly lower than that of the control group. Neither SD RR nor CV showed significant differences between the two groups, but both tended to be lower in the FMD group. In the frequency domain analysis, the HF component of the FMD group was significantly lower than that of the control group. Pulse pressure (PP) was significantly lower in the FMD subjects. These findings suggest that parasympathetic nervous dysfunction might exist in FMD patients, who were exposed to high doses of methylmercury (MeHg) during the prenatal period. Decrease of PP might be due to degenerative changes of blood vessels driven by exposure to high doses of MeHg. - fetal type Minamata disease; autonomic nervous functions; heart rate variability; methylmercury (C) 2002 Tohoku University Medical Press.