Amygdala activity at encoding correlated with long-term, free recall of emotional information
Amygdala activity at encoding correlated with long-term, free recall of emotional information
复制标题
DOI：
10.1073/pnas.93.15.8016
复制
发表时间：
1996-07-23
影响因子：
11.1
通讯作者：
McGaugh, JL
中科院分区：
文献类型：
--
作者：
Cahill, L;Haier, RJ;McGaugh, JL
使用成人受试者大脑葡萄糖代谢的正电子发射断层扫描来研究与情绪唤起事件的长期记忆存储相关的杏仁核复合物（AC）活性。受试者观看两个视频（两个独立的正电子发射断层扫描会话各一个，间隔 3-7 天），其中包含 12 个情绪激动的电影剪辑（“E”电影会话）或 12 个相对情感中性的电影剪辑（“N”电影会话），并在观看后立即评估他们对每个电影剪辑的情绪反应。第二个会话后三周，在免费回忆测试中评估视频的记忆， 正如预期的那样，受试者对 E 部电影的平均情绪反应高于 N 部电影。此外，受试者回忆起的 E 部电影明显多于 N 部电影。观看 E 片时右侧 AC 的葡萄糖代谢率与回忆的 E 片数量高度相关。 AC 活动与回忆的 N 部电影数量没有显着相关性。研究结果支持了动物和人类研究得出的观点，即 AC 选择性地参与与情绪唤起事件相关的增强长期记忆的形成。
Positron emission tomography of cerebral glucose metabolism in adult human subjects was used to investigate amygdaloid complex (AC) activity associated with the storage of long-term memory for emotionally arousing events. Subjects viewed two videos (one in each of two separate positron emission tomography sessions, separated by 3-7 days) consisting either of 12 emotionally arousing film clips (''E'' film session) or of 12 relatively emotionally neutral film clips (''N'' film session), and rated their emotional reaction to each film clip immediately after viewing it, Three weeks after the second session, memory for the videos was assessed in a free recall test, As expected, the subjects' average emotional reaction to the E films was higher than that for the N films. In addition, the subjects recalled significantly more E films than N films. Glucose metabolic rate of the right AC while viewing the E films was highly correlated with the number of E films recalled. AC activity was not significantly correlated with the number of N films recalled, The findings support the view derived from both animal and human investigations that the AC is selectively involved with the formation of enhanced long-term memory associated with emotionally arousing events.