System Architecture of the LabPET Small Animal PET Scanner
System Architecture of the LabPET Small Animal PET Scanner
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DOI：
10.1109/tns.2008.2002326
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发表时间：
2008-10-01
影响因子：
1.8
通讯作者：
Fontaine, Rejean
中科院分区：
文献类型：
--
作者：
Tetrault, Mare-Andre;Viscogliosi, Nicolas;Fontaine, Rejean
为了满足现代分子成像的要求，舍布鲁克大学开发了一种用于小动物的数字正电子发射断层扫描（PET）扫描仪。基于耦合到LYSO/LGSO phoswich探测器的雪崩光电二极管（APD）的单独读出，扫描仪在16.2 cm直径、11.25 cm轴向视场中支持多达4608个通道，在视场中心具有类似于1.2 mm FWHM固有空间分辨率的各向同性。定制数据采集板以45 MHz对APD信号进行预处理和采样，并以高达1250原始计数每秒每mm（2）（10 000 cps/通道）的平均持续速率计算所检测事件的真实的时间晶体识别、能量和定时信息。真实的时间数字信号分析还过滤掉具有晶体粒度的预选能量窗口之外的事件，以消除康普顿事件和电子噪声。保留的事件，然后合并成一个单一的流通过实时排序树，在结束提示和延迟的巧合被提取。一个单一的火线链接处理控制和数据传输与主机。LabPET具有四种数据记录模式，用户可以选择保留数据用于研究，或最大限度地减少文件大小以实现高符合计数率和成像目的。电子系统还支持用于标记的时间同步数据插入，例如门控图像重建中使用的生命体征。除了数据采集外，硬件还可以生成适用于快速自动通道校准的实时能量和鉴别光谱。
To address modern molecular imaging requirements, a digital positron emission tomography (PET) scanner for small animals has been developed at Universite de Sherbrooke. Based on individual readout of avalanche photodiodes (APD) coupled to LYSO/LGSO phoswich detectors, the scanner supports up to 4608 channels in a 16.2 cm diameter, 11.25 cm axial field of view with an isotropic similar to 1.2 mm FWHM intrinsic spatial resolution at the center of the field of view. Custom data acquisition boards preprocess and sample APD signals at 45 MHz and compute in real time crystal identification, energy and timing information of detected events at an average sustained rate of up to 1250 raw counts per second per mm(2) (10 000 cps/channel). Real time digital signal analysis also filters out events outside the pre-selected energy window with crystal granularity to eliminate Compton events and electronic noise. Retained events are then merged into a single stream through a real-time sorting tree, at which end prompt and delayed coincidences are extracted. A single Firewire link handles both control and data transfers with a host computer. The LabPET features four data recording modes, giving the user the choice to retain data for research or to minimize file size for high coincidence count rate and imaging purposes. The electronic system also supports time synchronized data insertion for flags such as vital signs used in gated image reconstruction. Aside from data acquisition, hardware can generate live energy and discrimination spectra suitable for fast, automatic channel calibration.