Autoimmune effector memory T cells: the bad and the good.
Autoimmune effector memory T cells: the bad and the good.
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DOI：
10.1007/s12026-013-8448-1
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发表时间：
2013-12
影响因子：
4.4
通讯作者：
Chen, Zhibin
中科院分区：
文献类型：
--
作者：
Devarajan, Priyadharshini;Chen, Zhibin
免疫记忆是适应性免疫的一个标志，适应性免疫是脊椎动物在进化过程中赋予的一种防御机制。然而，随着证据的不断积累，记忆淋巴细胞的自身免疫致病作用也正在出现，尽管人们对它们在自身免疫损伤的慢性环境中的存在存在合理怀疑。可以想象，自身免疫记忆会特别有害，因为记忆细胞会不断“记忆”并攻击身体的健康组织。考虑到记忆 T 细胞对免疫调节疗法的抵抗力，它的危害性更大。在这篇综述中，我们重点关注自身抗原反应性 CD4+ 效应记忆 T (TEM) 细胞，调查 TEM 区室在自身免疫发病机制中作用的证据。我们还将讨论 TEM 细胞在慢性和急性传染病环境中的作用，以及它们如何与自身免疫性疾病中的对应细胞进行比较。凭借其持久的效力，自身免疫 TEM 细胞也可以在抗肿瘤免疫中发挥关键作用，这可能很大程度上取决于它们对自身抗原的反应性。因此，尽管自身免疫 TEM 细胞由于在自身免疫性疾病环境中不断造成组织损伤而“有害”，但它们不太可能是现代自身免疫性疾病患病率激增过程中工业发展的副产品。相反，它们可能是进化的产物，因为它们在清除慢性感染中受损的宿主细胞和癌症环境中的恶性细胞方面具有“好处”。
Immunological memory is a hallmark of adaptive immunity, a defense mechanism endowed to vertebrates during evolution. However, an autoimmune pathogenic role of memory lymphocytes is also emerging with accumulating evidence, despite reasonable skepticism on their existence in a chronic setting of autoimmune damage. It is conceivable that autoimmune memory would be particularly harmful since memory cells would constantly “remember” and attack the body's healthy tissues. It is even more detrimental given the resistance of memory T cells to immunomodulatory therapies. In this review, we focus on self-antigen-reactive CD4+ effector memory T (TEM) cells, surveying the evidence for the role of the TEM compartment in autoimmune pathogenesis. We will also discuss the role of TEM cells in chronic and acute infectious disease settings and how they compare to their counterparts in autoimmune diseases. With their long-lasting potency, the autoimmune TEM cells could also play a critical role in anti-tumor immunity, which may be largely based on their reactivity to self-antigens. Therefore, although autoimmune TEM cells are “bad” due to their role in relentless perpetration of tissue damage in autoimmune disease settings, they are unlikely a by-product of industrial development along the modern surge of autoimmune disease prevalence. Rather, they may be a product of evolution for their “good” in clearing damaged host cells in chronic infections and malignant cells in cancer settings.
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影响因子：
4.4
作者：
Bending, David;Zaccone, Paola;Cooke, Anne
通讯作者：
Cooke, Anne
DOI：
10.1073/pnas.0607854103
发表时间：
2006-10-31
影响因子：
11.1
作者：
Chen, Zhibin;Stockton, John;Benoist, Christophe
通讯作者：
Benoist, Christophe
影响因子：
11.2
作者：
Ambrosino, Elena;Spadaro, Michela;Cavallo, Federica
通讯作者：
Cavallo, Federica
全基因组关联研究人类基因组多样性项目人群中的 SNP：选择是否会影响具有共享性状关联的不相关 SNP？
影响因子：
4.5
作者：
Casto AM;Feldman MW
通讯作者：
Feldman MW
影响因子：
3.7
作者：
Corona E;Dudley JT;Butte AJ
通讯作者：
Butte AJ