Disentangling Hippocampal and Amygdala Contribution to Human Anxiety-Like Behavior
Disentangling Hippocampal and Amygdala Contribution to Human Anxiety-Like Behavior
复制标题
DOI：
10.1523/jneurosci.0412-19.2019
复制
发表时间：
2019-10-23
影响因子：
5.3
通讯作者：
Ploner, Christoph J.
中科院分区：
文献类型：
--
作者：
Bach, Dominik R.;Hoffmann, Martina;Ploner, Christoph J.
焦虑包括一系列处理潜在威胁的行为，通常被模拟在接近-避免冲突任务中。总的来说，这些测试构成了焦虑症的主要临床前模型。大量证据表明，腹侧海马体和杏仁核损害都会损害焦虑样行为，但这两种结构的相对作用尚不清楚。一个可能的原因是，接近-避免冲突任务涉及一系列决定和行动，这些决定和行动可能由不同的神经机制控制，这些机制很难从行为读数中分离出来。在这里，我们利用了一种以电脑游戏形式实现的人类接近-避免冲突测试，该测试分别测量了几个动作组成部分。我们调查了三名非特异性单侧内侧颞叶(MTL)损害的患者，一名男性患者患有选择性双侧海马(HC)，一名女性患者患有选择性双侧杏仁核损害，并将他们与匹配的对照组进行比较。MTL和选择性HC损害，而不是选择性杏仁核损害，在可能损失较高时增加了入路决定。相反，MTL和选择性杏仁核损害，而不是选择性HC损害，增加了返回潜伏期。此外，选择性HC和选择性杏仁核损毁减少了接近潜伏期。在一项旨在揭示关于电脑游戏结构的主观假设的任务中，MTL和选择性HC损害影响反应时产生，但不影响主观任务结构。我们的结论是，决定在受到威胁时接近奖励依赖于海马体，而不是杏仁核，而回到安全状态的活力取决于杏仁核，而不是海马体。
Anxiety comprises a suite of behaviors to deal with potential threat and is often modeled in approach-avoidance conflict tasks. Collectively, these tests constitute a predominant preclinical model of anxiety disorder. A body of evidence suggests that both ventral hippocampus and amygdala lesions impair anxiety-like behavior, but the relative contribution of these two structures is unclear. A possible reason is that approach-avoidance conflict tasks involve a series of decisions and actions, which may be controlled by distinct neural mechanisms that are difficult to disentangle from behavioral readouts. Here, we capitalize on a human approach-avoidance conflict test, implemented as computer game, that separately measures several action components. We investigate three patients of both sexes with unspecific unilateral medial temporal lobe (MTL) damage, one male with selective bilateral hippocampal (HC), and one female with selective bilateral amygdala lesions, and compare them to matched controls. MTL and selective HC lesions, but not selective amygdala lesions, increased approach decision when possible loss was high. In contrast, MTL and selective amygdala lesions, but not selective HC lesions, increased return latency. Additionally, selective HC and selective amygdala lesions reduced approach latency. In a task targeted at revealing subjective assumptions about the structure of the computer game, MTL and selective HC lesions impacted on reaction time generation but not on the subjective task structure. We conclude that deciding to approach reward under threat relies on hippocampus but not amygdala, whereas vigor of returning to safety depends on amygdala but not on hippocampus.