Low-frequency theta oscillations in the human hippocampus during real-world and virtual navigation.
Low-frequency theta oscillations in the human hippocampus during real-world and virtual navigation.
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DOI：
10.1038/ncomms14415
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发表时间：
2017-02-14
影响因子：
16.6
通讯作者：
Ekstrom AD
中科院分区：
文献类型：
--
作者：
Bohbot VD;Copara MS;Gotman J;Ekstrom AD
在现实世界中行走的啮齿动物身上，记录到了7-9 Hz或theta节律范围内的低频振荡。然而，人类在虚拟导航过程中的海马区脑电记录一直报告说，低频振荡似乎占主导地位，大约3-4 赫兹。在这里，我们报告了在真实和虚拟运动中原始海马区脑电轨迹中7-9 赫兹节律性的明显证据。在虚拟导航中，振荡通常发生在比现实世界更低的频率。这项研究强调了这样一种可能性，即人类和啮齿动物的海马区脑电活动并不像之前报道的那样不同，这种差异可能部分是由于以前的人类导航研究缺乏实际运动，这些研究是虚拟的。在航行过程中，啮齿类动物观察到在theta频率范围(7-9 HZ)内的节律性振荡。在这里，作者展示了在真实和虚拟运动中人类海马体中强大的相似的theta节律性。
Low-Frequency Oscillations (LFO) in the range of 7–9 Hz, or theta rhythm, has been recorded in rodents ambulating in the real world. However, intra-hippocampus EEG recordings during virtual navigation in humans have consistently reported LFO that appear to predominate around 3–4 Hz. Here we report clear evidence of 7–9 Hz rhythmicity in raw intra-hippocampus EEG traces during real as well as virtual movement. Oscillations typically occur at a lower frequency in virtual than real world navigation. This study highlights the possibility that human and rodent hippocampal EEG activity are not as different as previously reported and this difference may arise, in part, due to the lack of actual movement in previous human navigation studies, which were virtual. Rhythmic oscillations in theta frequency range (7–9 Hz) are observed in rodents during navigation. Here the authors demonstrate robust similar theta rhythmicity in human hippocampus during both real and virtual movements.