Current and emerging strategies for the prevention of graft-versus-host disease.
Current and emerging strategies for the prevention of graft-versus-host disease.
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DOI：
10.1038/nrclinonc.2014.102
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Reddy P
中科院分区：
文献类型：
--
作者：
Choi SW;Reddy P
Graft-versus-host disease (GVHD) represents the most serious and challenging complication of allogeneic haematopoietic stem-cell transplantation (HSCT). New insights on the role of regulatory T cells, T cells, and antigen presenting cells have led to improved understanding of the pathophysiology of GVHD. However, little progress has been made since the introduction of calcineurin-inhibitor-based regimens in the mid-1980s. Despite standard prophylaxis with these regimens, GVHD still develops in approximately 40–60% of recipients. Thus, there is a need for developing newer approaches to mitigate GVHD, which may facilitate the use of allogeneic HCT for the treatment of a wider range of haematological cancers. We will discuss the rationale, clinical evidence, and outcomes of current (and widely employed) strategies for GVHD prophylaxis, namely calcineurin-inhibitor-based regimen (such as cyclosporine or tacrolimus) combined with methotrexate or mycophenolate mofetil. We assess the clinical evidence for emerging approaches in the prevention of GVHD, including therapies targeting T cells or B cells, mesenchymal stem cells, the use of chemo-cytokine antagonists (such as maraviroc, TNF-α inhibitor, IL-2 receptor antagonist, IL-6 inhibitor), and the use of novel molecular regulators that target multiple cell types simultaneously (such as atorvastatin, bortezomib, and epigenetic modulators).
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影响因子：
20.3
作者：
Antin, JH;Kim, HT;Soiffer, RJ
通讯作者：
Soiffer, RJ
DOI：
10.1016/s1470-2045(13)70512-6
发表时间：
2014-01
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Choi SW;Braun T;Chang L;Ferrara JL;Pawarode A;Magenau JM;Hou G;Beumer JH;Levine JE;Goldstein S;Couriel DR;Stockerl-Goldstein K;Krijanovski OI;Kitko C;Yanik GA;Lehmann MH;Tawara I;Sun Y;Paczesny S;Mapara MY;Dinarello CA;DiPersio JF;Reddy P
通讯作者：
Reddy P
影响因子：
168.9
作者：
André-Schmutz, I;Le Deist, F;Cavazzana-Calvo, M
通讯作者：
Cavazzana-Calvo, M
影响因子：
20.3
作者：
Blanco, B;Pérez-Simón, JA;San Miguel, J
通讯作者：
San Miguel, J
影响因子：
4.3
作者：
Choi, Sung W.;Stiff, Patrick;Cooke, Kenneth;Ferrara, James L. M.;Braun, Thomas;Kitko, Carrie;Reddy, Pavan;Yanik, Gregory;Mineishi, Shin;Paczesny, Sophie;Hanauer, David;Pawarode, Attaphol;Peres, Edward;Rodriguez, Tulio;Smith, Scott;Levine, John E.
通讯作者：
Levine, John E.