Prevalent vertebral deformities predict increased mortality and increased fracture rate in both men and women: A 10-year population-based study of 598 individuals from the Swedish cohort in the European Vertebral Osteoporosis Study
Prevalent vertebral deformities predict increased mortality and increased fracture rate in both men and women: A 10-year population-based study of 598 individuals from the Swedish cohort in the European Vertebral Osteoporosis Study
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DOI：
10.1007/s00198-002-1316-9
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发表时间：
2003-01-01
影响因子：
4
通讯作者：
Johnell, O
中科院分区：
文献类型：
--
作者：
Hasserius, R;Karlsson, MK;Johnell, O
本研究的目的是评估普遍的椎骨畸形是否可以预测男性和女性的死亡率和骨折。 In the city of Malmo, 598 individuals (298 men, 300 women; age 50-80 years) were selected from the city's population and were included in the Swedish part of the European Vertebral Osteoporosis Study (EVOS).在基线时，参与者回答了一份问卷，并进行了脊柱侧位X光检查。使用形态测量方法评估椎体畸形受试者的患病率。 10 年随访期间的死亡率是通过瑞典国家健康和福利委员会的登记册确定的。研究期间有 85 名男性和 43 名女性死亡。 The subsequent fracture incidence during the follow-up period was ascertained by postal questionnaires, telephone interviews and by a survey of the archives of the Department of Radiology in the city hospital.在研究期间，37 名男性和 69 名女性发生骨折。数据以危险比 (HR) 形式呈现，括号内为 95% 置信区间 (95% CI)。 Prevalent vertebral deformity, defined as a reduction by more than 3 standard deviations (SD) in vertebral height ratio, predicted mortality during the forthcoming decade in both men [age-adjusted HR 2.4 (95% Cl 1.6-3.9)] and women [age-adjusted HR 2.3 (95% Cl 1.3-4.3)].男性因心血管和肺部疾病导致的死亡率增加，女性因癌症导致的死亡率增加。 Prevalent vertebral deformity predicted an increased risk of any fracture during the forthcoming decade in both men [age-adjusted HR 2.7 (95% Cl 1.4-5.3)] and women [age-adjusted HR 1.8 (95% Cl 1.1-2.9)].普遍存在的椎骨畸形预示着女性随后出现脆性骨折的风险会增加[年龄调整 HR 2.0 (95% Cl 1.1-3.5)]；然而，在男性中，风险增加并不显着[年龄调整 HR 1.9 (95% CI 0.7-5.1)]。 In summary, a prevalent vertebral deformity can predict both increased mortality and increased fracture incidence during the following decade in both men and women.我们的结论是，普遍的椎骨畸形可以作为男女死亡和未来骨折的危险因素。
The aim of this study was to evaluate whether a prevalent vertebral deformity predicts mortality and fractures in both men and women. In the city of Malmo, 598 individuals (298 men, 300 women; age 50-80 years) were selected from the city's population and were included in the Swedish part of the European Vertebral Osteoporosis Study (EVOS). At baseline the participants answered a questionnaire and lateral spine radiographs were performed. The prevalence of subjects with vertebral deformity was assessed using a morphometric method. The mortality during a 10-year follow-up period was determined through the register of the National Swedish Board of Health and Welfare. Eighty-five men and 43 women died during the study period. The subsequent fracture incidence during the follow-up period was ascertained by postal questionnaires, telephone interviews and by a survey of the archives of the Department of Radiology in the city hospital. Thirty-seven men and 69 women sustained a fracture during the study period. Data are presented as hazard ratios (HR) with 95% confidence interval (95% CI) within brackets. Prevalent vertebral deformity, defined as a reduction by more than 3 standard deviations (SD) in vertebral height ratio, predicted mortality during the forthcoming decade in both men [age-adjusted HR 2.4 (95% Cl 1.6-3.9)] and women [age-adjusted HR 2.3 (95% Cl 1.3-4.3)]. In men there was an increased mortality due to cardiovascular and pulmonary diseases and in women due to cancer. Prevalent vertebral deformity predicted an increased risk of any fracture during the forthcoming decade in both men [age-adjusted HR 2.7 (95% Cl 1.4-5.3)] and women [age-adjusted HR 1.8 (95% Cl 1.1-2.9)]. Prevalent vertebral deformity predicted an increased risk of any subsequent fragility fracture in women [age-adjusted HR 2.0 (95% Cl 1.1-3.5)]; however, in men the increased risk was nonsignificant [age-adjusted HR 1.9 (95% CI 0.7-5.1)]. In summary, a prevalent vertebral deformity can predict both increased mortality and increased fracture incidence during the following decade in both men and women. We conclude that prevalent vertebral deformity could be used as a risk factor in both genders for mortality and future fracture.