Changes in expression of murine leukemia virus antigens and production of xenotropic virus in the late preleukemic period in AKR mice.
Changes in expression of murine leukemia virus antigens and production of xenotropic virus in the late preleukemic period in AKR mice.
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AKR 小鼠白血病前期晚期鼠白血病病毒抗原表达和异种病毒产生的变化。
DOI：
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发表时间：
1976
影响因子：
11.1
通讯作者：
L. Old
中科院分区：
文献类型：
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作者：
K. Kawashima;H. Ikeda;J. Hartley;E. Stockert;W. Rowe;L. Old
我们最近报道，6 个月大的白血病前期 AKR 小鼠的胸腺细胞比 2 个月大的小鼠的胸腺细胞表达更高水平的鼠白血病病毒 (MuLV) 相关抗原。我们现在发现，6 个月大的 AKR 小鼠胸腺中异种 MuLV（操作上定义为能够感染水貂细胞培养物的 MuLV）水平也显着增加，并且病毒的这种增加与 MuLV 抗原表达的增加密切相关。脾脏或淋巴结中MuLV抗原或异种病毒没有增加。随着年龄的增长，胸腺、淋巴结和脾脏中亲向性 MuLV 的产生保持不变。来自 6 个月大的 AKR 小鼠（而非 2 个月大的小鼠）的胸腺移植物会诱导年轻 AKR 受体胸腺中 MuLV 抗原表达的扩增和异种病毒的产生。用同基因骨髓细胞重组的经致死辐射的 AKR 小鼠进行的实验表明，胸腺中与年龄相关的变化而不是骨髓前体细胞中的变化是 MuLV 抗原扩增的原因。
We recently reported that thymocytes from 6-month-old preleukemic AKR mice express higher levels of murine leukemia virus (MuLV)-related antigens that thymocytes from 2-month-old mice. We have now found that the level of xenotropic MuLV (defined operationally as MuLV able to infect mink cell cultures) is also markedly increased in thymus of 6-month-old AKR mice and that this increase in virus correlates closely with increased MuLV-antigen expression. There is no increase of MuLV antigen or xenotropic virus in spleen or lymph nodes. Production of ecotropic MuLV remains unchanged with age in thymus, lymph nodes, and spleen. Thymic grafts from 6-month-old AKR mice, but not from 2-month-old mice, induce both amplified MuLV-antigen expression and xenotropic virus production in the thymus of young AKR recipients. Experiments with lethally irradiated AKR mice reconstituted with syngeneic bone marrow cells indicate that age-related changes in the thymus rather than in bone marrow precursor cells are responsible for MuLV-antigen amplification.