In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography.
In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography.
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DOI：
10.1364/ol.39.005594
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发表时间：
2014-10-01
期刊：
影响因子：
3.6
通讯作者：
Wax A
中科院分区：
文献类型：
--
作者：
Maher JR;Jaedicke V;Medina M;Levinson H;Selim MA;Brown WJ;Wax A
生物组织的光谱分析可以深入了解疾病或损伤引起的结构和功能变化。深度分辨光谱测量可以实现组织成像使用光学相干断层扫描（OCT）。在这里，光谱OCT被应用于烧伤小鼠模型的体内测量。比较了数据处理和分析方法的准确性。发现烧伤组织分类的总体准确率高达91%，产生接受者操作者特征曲线下面积为0.97。光谱变化的起源是通过与组织病理学的相关性来确定的。
Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operator characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology.