Fabrication of carbonate apatite foam based on the setting reaction of α-tricalcium phosphate foam granules
Fabrication of carbonate apatite foam based on the setting reaction of α-tricalcium phosphate foam granules
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DOI：
10.1016/j.ceramint.2015.08.081
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发表时间：
2016-01-01
影响因子：
5.2
通讯作者：
Ishikawa, Kunio
中科院分区：
文献类型：
--
作者：
Sugiura, Yuki;Tsuru, Kanji;Ishikawa, Kunio
碳酸磷灰石泡沫作为骨替代材料和组织再生支架材料已引起人们的关注。本研究以α-磷酸三钙（alpha-TCP）泡沫颗粒的凝固反应为基础，对制备CO 3 Ap泡沫的可行性进行了评价。当α-TCP泡沫颗粒在NaHCO 3溶液存在下于200 ℃水热处理24 h时，形成CO（3）Ap泡沫。沉淀的CO（3）Ap晶体彼此互锁以形成CO（3）Ap泡沫。在含有高NaHCO 3的溶液中形成的CO 3Ap被认为是B型CO（3）Ap，其是在骨骼中发现的CO（3）Ap，并且含有0.85质量%的CO 3。当α-TCP泡沫颗粒在较高的NaHCO 3溶液中处理时，磷灰石结构中的CO 3含量增加，并且改变了CO（3）Ap的形貌，从纤维状变为具有较小长径比的板状，因此，凝固能力消失。2015 Elsevier Ltd和Techna Group S.r.l. All rights reserved.
Carbonate apatite (CO(3)Ap) foam has attracted attention as a bone substitute and scaffold for tissue regeneration. In this study, the feasibility of fabricating CO(3)Ap foam was evaluated on the basis of the setting reaction of alpha-tricalcium phosphate (alpha-TCP) foam granules. CO(3)Ap foam was formed when alpha-TCP foam granules were treated hydrothermally at 200 degrees C in the presence of NaHCO3 solution for 24 h. The precipitated CO(3)Ap crystals interlocked with each other to form the CO(3)Ap foam. The CO3Ap formed in high NaHCO3 containing solution was considered to be a B-type CO(3)Ap, which is the CO(3)Ap found in bones and contained 0.85 mass% CO3. When the alpha-TCP foam granules were treated at higher NaHCO3 solution, the content of the CO3 in the apatitic structure increased and changed the morphology of the CO(3)Ap from fiber-like to plate-like with a smaller aspect ratio; thus, the setting ability disappeared. 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.