Colloidal sorting in dynamic optical lattices
Colloidal sorting in dynamic optical lattices
复制标题
DOI：
10.1088/1464-4258/9/8/s05
复制
发表时间：
2007-08
影响因子：
2.1
通讯作者：
Ryan L. Smith;G. Spalding;K. Dholakia;M. Macdonald
中科院分区：
文献类型：
--
作者：
Ryan L. Smith;G. Spalding;K. Dholakia;M. Macdonald
基于粒子与光学定义的势能景观相互作用的被动微流控分选技术可能比主动分选技术（如微荧光激活细胞分选（FACS））具有优势，包括易于集成到芯片实验室系统中，可重构性和可扩展性。而不是一个接一个地分析和偏转单个文件的粒子流，本质上旨在并行处理的被动方法可能最终提供更大的高吞吐量潜力。然而，试图在高密度悬浮液中同时对许多颗粒进行分选，不可避免地受到颗粒-颗粒相互作用的限制，这导致分选效率的降低。在本文中，我们描述了两种不同的方法，旨在减少胶体交通流问题。我们发现，排序晶格的连续平移有助于减少最近邻居粒子间距，为未来高通量应用的效率提高提供了希望，并且闪烁晶格可以减少不必要的堆积和溢出效应，否则会限制排序效率。
Passive microfluidic sorting techniques based upon the interaction of particles with an optically defined potential energy landscape have possible advantages over active sorting techniques such as microfluorescence activated cell sorting (FACS), including ease of integration into lab-on-a-chip systems, reconfigurability, and scalability. Rather than analysing and deflecting a single-file stream of particles one by one, a passive approach intrinsically aimed at parallel processing may, ultimately, offer greater potential for high throughput. However attempts to sort many particles simultaneously in high density suspensions are inevitably limited by particle–particle interactions, which lead to a reduction in the efficiency of the sorting. In this paper we describe two different approaches aimed at reducing colloidal traffic flow problems. We find that continuous translation of the sorting lattice helps to reduce nearest neighbour particle spacing, providing promise for efficiency improvements in future high throughput applications, and that a flashing lattice yields a reduction in unwanted pile-up and spillover effects which otherwise limit the efficiency of sorting.