Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain
Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain
复制标题
DOI：
10.1016/j.neuroimage.2006.02.038
复制
发表时间：
2006-07-15
期刊：
影响因子：
5.7
通讯作者：
Hebden, J. C.
中科院分区：
文献类型：
--
作者：
Austin, T.;Gibson, A. P.;Hebden, J. C.
光学方法提供了一种监测新生儿脑损伤风险的脑氧合的手段。开发了一种32通道光学成像系统，用于重建区域血容量和氧合的三维图像。研究人员从24名婴儿中的14名获得了完整的图像数据集；其中8个婴儿的图像已成功重建。健康早产儿脑血容量和组织氧饱和度存在区域差异。在一个单侧大脑室内出血的婴儿中，检测到相应的低氧饱和度区域。这些结果表明，光学断层扫描可以提供一种合适的技术来研究区域脑血流动力学和脑外氧合。(c) 2006爱思唯尔公司版权所有。
Optical methods provide a means of monitoring cerebral oxygenation in newborn infants at risk of brain injury. A 32-channel optical imaging system has been developed with the aim of reconstructing three-dimensional images of regional blood volume and oxygenation. Full image data sets were acquired from 14 out of 24 infants studied; successful images have been reconstructed in 8 of these infants. Regional variations in cerebral blood volume and tissue oxygen saturation are present in healthy preterm infants. In an infant with a large unilateral intraventricular haemorrhage, a corresponding region of low oxygen saturation was detected. These results suggest that optical tomography may provide an appropriate technique for investigating regional cerebral haemodynamics and oxygenation at the cotside. (c) 2006 Elsevier Inc. All rights reserved.