Nivolumab causes focal muscular inflammation without electrophysiological or muscle magnetic resonance imaging findings
Nivolumab causes focal muscular inflammation without electrophysiological or muscle magnetic resonance imaging findings
复制标题
纳武单抗引起局灶性肌肉炎症，但没有电生理或肌肉磁共振成像发现
DOI：
10.1111/ncn3.12193
复制
发表时间：
2018
影响因子：
0.4
通讯作者：
and Takahashi R
中科院分区：
文献类型：
--
作者：
Li F;Ayaki T;Sakiho Ueda;Nagai H;Murata K;and Takahashi R
一名62岁的女性在接受纳武利尤单抗治疗后入院，主诉双侧肩部肌肉疼痛。她的实验室数据显示血清肌酸激酶水平升高，而磁共振成像和肌电图研究无异常。进行左侧三角肌活检，发现肌纤维周围局灶性炎性细胞浸润和主要组织相容性复合物I类上调的证据。纳武利尤单抗给药后，即使是轻微和短暂的肌肉症状也可能代表免疫介导的肌肉炎症。
A 62‐year‐old woman was admitted to our hospital complaining of bilateral shoulder muscle pain after nivolumab treatment. Her laboratory data disclosed elevated serum creatine kinase levels while the magnetic resonance imaging and the electromyography study were unremarkable. A left deltoid muscle biopsy was performed, and the evidence of focal inflammatory cell infiltration surrounding muscle fibers and upregulation of major histocompatibility complex class I was showed. Even mild and transient muscular symptoms after administration of nivolumab can represent immune‐mediated muscular inflammation.