Unfavorable effect of small tumor size on cause-specific survival in stage IIA colon cancer, a SEER-based study
Unfavorable effect of small tumor size on cause-specific survival in stage IIA colon cancer, a SEER-based study
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DOI：
10.1007/s00384-014-2056-y
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发表时间：
2015-01-01
影响因子：
2.8
通讯作者：
Cai, Guoxiang
中科院分区：
文献类型：
--
作者：
Wang, Yuwei;Zhuo, Changhua;Cai, Guoxiang
背景：我们试图确定肿瘤大小对IIA期结肠癌患者的原因特异性生存（CSS）的预后作用。方法：利用监测、流行病学和最终结果（SEER）数据库确定1988年至2003年诊断的IIA期结直肠癌患者（检查淋巴结的千分之十二）。通过单因素和多因素分析评价肿瘤大小对CSS预后的影响。中位随访时间为109个月。如通过最小P值方法确定的，使用2.5和6.0 cm的肿瘤大小作为划分队列的最佳截止值。肿瘤大小为千分之2.5、2.6-6.0和> 6.0 cm的结肠癌8年生存率分别为81.6、86.2和86.7%（P = 0.003）。在结肠癌的多变量分析中，以千分之一货币符号2.5-cm肿瘤为参考，在2.6-6.0 cm肿瘤中观察到CSS的风险比（HR）降低（HR，0.736; 95%置信区间（CI），0.599-0.905; P = 0.004）和> 6.0 cm（HR，0.770; 95% CI，0.619-0.958; P = 0.019）结论在IIA期结肠癌中，小肿瘤大小代表CSS降低的亚组。进一步的研究是值得的，以验证小肿瘤大小在IIA期结肠癌的不利预后作用。
Background We sought to determine the prognostic role of tumor size on cause-specific survival (CSS) of patients with stage IIA colon cancer.Methods Surveillance, Epidemiology and End Results (SEER) database was utilized to identify patients with stage IIA colorectal cancer (examined lymph nodes a parts per thousand yen12) diagnosed from 1988 to 2003. The prognostic effect of tumor size on CSS was evaluated by univariate and multivariate analyses.Results A total of 8775 patients were enrolled in the analysis. The median follow-up time was 109 months. As determined by minimal P value method, tumor sizes of 2.5 and 6.0 cm were used as optimal cutoff value to divide the cohort. The 8-year CSS of colon cancer with tumor sizes a parts per thousand currency sign2.5, 2.6-6.0, and > 6.0 cm was 81.6, 86.2, and 86.7 % respectively (P = 0.003). In the multivariate analysis of colon cancer, using a parts per thousand currency sign2.5-cm tumors as reference, decreased hazard ratio (HR) of CSS was observed in 2.6-6.0 cm (HR, 0.736; 95 % confidence interval (CI), 0.599-0.905; P = 0.004) and > 6.0 cm (HR, 0.770; 95 % CI, 0.619-0.958; P = 0.019) tumors.Conclusions In stage IIA colon cancer, small tumor size represented a subset with decreased CSS. Further studies are merited to validate the unfavorable prognostic role of small tumor size in stage IIA colon cancer.