Mitral valve closure prediction with 3-D personalized anatomical models and anisotropic hyperelastic tissue assumptions.
Mitral valve closure prediction with 3-D personalized anatomical models and anisotropic hyperelastic tissue assumptions.
复制标题
使用 3D 个性化解剖模型和各向异性超弹性组织假设进行二尖瓣关闭预测。
DOI：
10.1109/tbme.2013.2272075
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Burlina,P
中科院分区：
文献类型：
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作者：
Sprouse,C;Mukherjee,R;Burlina,P
本研究涉及开发针对患者的二尖瓣模拟，该模拟使用源自 3-D 经食管超声心动图 (3-D TEE) 的个性化解剖模型。所提出的方法通过求解平衡各种力（包括血压、组织碰撞、瓣膜束缚和组织弹性）的平衡解来预测二尖瓣的闭合配置。该模型还结合了瓣膜小叶的真实超弹性和各向异性特性。本研究比较了各种生理参数下的超弹性组织定律与准弹性定律，并深入了解了弦放置的误差敏感性，从而可以初步比较两个因素（弦和模型）对误差的影响。预测误差显示了该方法的前景，产生的总中值误差约为 1 毫米，计算出的应变和应力与先前研究中报告的结果具有良好的一致性。
This study is concerned with the development of patient-specific simulations of the mitral valve that use personalized anatomical models derived from 3-D transesophageal echocardiography (3-D TEE). The proposed method predicts the closed configuration of the mitral valve by solving for an equilibrium solution that balances various forces including blood pressure, tissue collision, valve tethering, and tissue elasticity. The model also incorporates realistic hyperelastic and anisotropic properties for the valve leaflets. This study compares hyperelastic tissue laws with a quasi-elastic law under various physiological parameters, and provides insights into error sensitivity to chordal placement, allowing for a preliminary comparison of the influence of the two factors (chords and models) on error. Predictive errors show the promise of the method, yielding aggregate median errors of the order of 1 mm, and computed strains and stresses show good correspondence with those reported in prior studies.