Induction of Complete Remission of Hypoplastic Leukemia with Antithymocyte Globulin
Induction of Complete Remission of Hypoplastic Leukemia with Antithymocyte Globulin
复制标题
抗胸腺细胞球蛋白诱导发育不全性白血病完全缓解
DOI：
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发表时间：
2003
影响因子：
2.1
通讯作者：
S. Kojima
中科院分区：
文献类型：
--
作者：
A. Yoshimi;Chikako Nakamoto;Yoichi Nakamura;Koji Kato;T. Matsuyama;K. Kudo;S. Kojima
一名13岁的男孩因全血细胞减少症住进了当地医院。骨髓穿刺和活组织检查显示骨髓细胞严重减少，没有明显的白血病细胞。诊断为重度再生障碍性贫血，患者接受抗胸腺细胞球蛋白和环孢菌素A治疗。获得了三系反应，患者在2周内变得不依赖输血。两个月后，外周血细胞计数正常化，骨髓细胞增加。然而，5个月后患者因全血细胞减少症复发再次入院。骨髓穿刺显示骨髓细胞减少，具有形态学上的母细胞样细胞。表面标志物研究显示存在一个单一的克隆，是阳性的CD 7，CD 33，CD 34，和HLA-DR。一个发育不良性白血病的诊断的基础上的形态学和表面标志物的研究。回顾性分析，实验室检查结果与疾病发作时相同。患者对长春新碱、泼尼松龙、环磷酰胺、左旋门冬酰胺酶和多柔比星联合化疗无反应，但给予足叶乙甙后完全缓解。体外研究表明，该患者的白血病细胞在与抗胸腺细胞球蛋白和人AB血清或幼兔血清孵育后可裂解>95%。这些发现表明抗胸腺细胞球蛋白治疗某些再生不良性白血病的疗效。
A 13-year-old boy was admitted to a local hospital because of pancytopenia. A bone marrow aspiration and biopsy revealed severely hypocellular marrow with no obvious leukemic cells. The diagnosis was severe aplastic anemia, and the patient was treated with antithymocyte globulin and cyclosporin A. A trilineage response was obtained, and the patient became transfusion-independent within 2 weeks. Two months later, the peripheral blood count normalized with an increased bone marrow cellularity. However, the patient was readmitted 5 months later for recurrence of the pancytopenia. A bone marrow aspiration revealed hypocellular marrow with morphologically blastoid cells. A surface marker study revealed the presence of a single clone that was positive for CD7, CD33, CD34, and HLA-DR. A diagnosis of hypoplastic leukemia was made on the basis of morphology and the surface marker studies. Retrospectively, the laboratory findings were the same as those seen at the onset of the disease. The patient did not respond to combination chemotherapy consisting of vincristine, prednisolone, cyclophosphamide, L-asparaginase, and doxorubicin, but administration of etoposide resulted in complete remission. An in vitro study revealed that >95% of the leukemic cells of this patient could be lysed after an incubation with antithymocyte globulin and human AB serum or baby rabbit serum. These findings suggest the efficacy of antithymocyte globulin in treating certain hypoplastic leukemias.
影响因子：
20.3
作者：
D. Maloney;T. Liles;DK Czerwinski;C. Waldichuk;J. Rosenberg;A. Grillo‐López;R. Levy
通讯作者：
D. Maloney;T. Liles;DK Czerwinski;C. Waldichuk;J. Rosenberg;A. Grillo‐López;R. Levy
影响因子：
158.5
作者：
CHAMPLIN, R;HO, W;GALE, RP
通讯作者：
GALE, RP