GADOLINIUM INHIBITS MECHANOELECTRICAL TRANSDUCTION IN RABBIT CAROTID BARORECEPTORS - IMPLICATION OF STRETCH-ACTIVATED CHANNELS
GADOLINIUM INHIBITS MECHANOELECTRICAL TRANSDUCTION IN RABBIT CAROTID BARORECEPTORS - IMPLICATION OF STRETCH-ACTIVATED CHANNELS
复制标题
DOI：
10.1172/jci117605
复制
发表时间：
1994-12-01
影响因子：
15.9
通讯作者：
ABBOUD, FM
中科院分区：
文献类型：
--
作者：
HAJDUCZOK, G;CHAPLEAU, MW;ABBOUD, FM
钆 (Gd3+) 已被证明可以阻止机械电转导，而机械电转导被认为是通过拉伸激活通道介导的。我们研究了 Gd3+ 敏感通道在介导兔颈动脉窦压力感受器活动中的可能作用。在暴露于 Gd3+ 期间，颈动脉窦压力斜坡增加引起的压力感受器活性显着降低。这种抑制与剂量相关且可逆，并且与颈动脉窦壁力学的改变无关，因为压力-应变关系不受影响。当单压力感受器纤维和多压力感受器纤维对压力的反应被 Gd3+ 抑制时，藜芦碱会触发单压力感受器纤维和多压力感受器纤维的动作电位。这表明 Gd3+ 对孤立颈动脉窦中压力感受器的影响与其机械激活有关。结果表明，对Gd3+敏感的牵张激活离子通道可能是兔颈动脉窦压力感受器的机电传感器。
Gadolinium (Gd3+) has been shown to prevent mechanoelectrical transduction believed to be mediated through stretch-activated channels. We investigated the possible role of Gd3+-sensitive channels in mediating baroreceptor activity in the carotid sinus of rabbits. Baroreceptor activity induced by a ramp increase of carotid sinus pressure was reduced significantly during exposure to Gd3+. The inhibition was dose-related and reversible, and was not associated with alteration of carotid sinus wall mechanics as the pressure-strain relationship was unaffected. Veratrine triggered action potentials from single- and multiple-baroreceptor fibers when their response to pressure was inhibited by Gd3+. This suggests that the effect of Gd3+ on baroreceptors in the isolated carotid sinus was specific to their mechanical activation. The results suggest that stretch-activated ion channels sensitive to Gd3+ may be the mechanoelectrical transducers of rabbit carotid sinus baroreceptors.