The genomic origins of the world's first farmers.
The genomic origins of the world's first farmers.
复制标题
世界上第一批农民的基因组起源。
DOI：
10.1016/j.cell.2022.04.008
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发表时间：
2022-05-26
期刊：
影响因子：
64.5
通讯作者：
Excoffier, Laurent
中科院分区：
文献类型：
--
作者：
Marchi, Nina;Winkelbach, Laura;Schulz, Ilektra;Brami, Maxime;Hofmanova, Zuzana;Bloecher, Jens;Reyna-Blanco, Carlos S.;Diekmann, Yoan;Thiery, Alexandre;Kapopoulou, Adamandia;Link, Vivian;Piuz, Valerie;Kreutzer, Susanne;Figarska, Sylwia M.;Ganiatsou, Elissavet;Pukaj, Albert;Struck, Travis J.;Gutenkunst, Ryan N.;Karul, Necmi;Gerritsen, Fokke;Pechtl, Joachim;Peters, Joris;Zeeb-Lanz, Andrea;Lenneis, Eva;Teschler-Nicola, Maria;Triantaphyllou, Sevasti;Stefanovic, Sofija;Papageorgopoulou, Christina;Wegmann, Daniel;Burger, Joachim;Excoffier, Laurent
欧洲和西南亚第一批新石器时代农业人口的确切遗传起源，以及他们分化的过程和时间，在很大程度上仍不清楚。对高质量的古代基因组进行的基因组学建模表明，安纳托利亚和欧洲的早期农民是在上一次冰川盛期之后，由西南亚人口和严重瓶颈的西方狩猎-采集人口的多阶段混合而成的。此外，欧洲和安纳托利亚第一批农民的祖先在向西扩张活动范围的过程中经历了一段极端的基因漂移时期，这对他们的基因独特性做出了很大贡献。这个模型阐明了新石器时代过渡的根源的人口过程，并导致了对西南亚和欧洲在晚更新世和早全新世的人口历史的空间解释。欧洲HGS在大冰期期间与西南亚洲HGS分化欧洲HGS的低遗传多样性是由于强烈的LGM人口瓶颈西方早期农民的祖先是在LGM后的反复混杂后出现的，EFS在通过安纳托利亚的扩张过程中与西南部亚洲人强烈分化古代DNA分析和进化模拟允许对西南亚和欧洲的新石器时代人口的祖先进行追溯，以解决世界上第一批久居农民的遗传起源。
The precise genetic origins of the first Neolithic farming populations in Europe and Southwest Asia, as well as the processes and the timing of their differentiation, remain largely unknown. Demogenomic modeling of high-quality ancient genomes reveals that the early farmers of Anatolia and Europe emerged from a multiphase mixing of a Southwest Asian population with a strongly bottlenecked western hunter-gatherer population after the last glacial maximum. Moreover, the ancestors of the first farmers of Europe and Anatolia went through a period of extreme genetic drift during their westward range expansion, contributing highly to their genetic distinctiveness. This modeling elucidates the demographic processes at the root of the Neolithic transition and leads to a spatial interpretation of the population history of Southwest Asia and Europe during the late Pleistocene and early Holocene. European HGs diverged from SW Asian HGs during the LGM Low genetic diversity of European HGs is due to a strong LGM demographic bottleneck Ancestors of western early farmers emerged after repeated post-LGM admixtures EFs strongly diverged from SW Asians during their expansion through Anatolia Ancient DNA analysis and evolutionary modeling have allowed for the ancestral tracing of the Neolithic populations of Southwest Asia and Europe to resolve the genetic origins of the world’s first sedentary farmers.
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影响因子：
10.7
作者：
Aime, Carla;Laval, Guillaume;Austerlitz, Frederic
通讯作者：
Austerlitz, Frederic
影响因子：
0.8
作者：
Baird, Douglas;Asouti, Eleni;Pirie, Anne
通讯作者：
Pirie, Anne
DOI：
10.1534/g3.117.300259
发表时间：
2017-11-06
期刊：
G3 (Bethesda, Md.)
影响因子：
--
作者：
Beichman AC;Phung TN;Lohmueller KE
通讯作者：
Lohmueller KE
影响因子：
8.3
作者：
Bonsall, Clive;Vasic, Rastko;Cook, Gordon
通讯作者：
Cook, Gordon
影响因子：
6.8
作者：
AKAIKE, H
通讯作者：
AKAIKE, H