A multicenter survey of enteroscopy for the diagnosis of intestinal follicular lymphoma
A multicenter survey of enteroscopy for the diagnosis of intestinal follicular lymphoma
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DOI：
10.3892/ol.2015.3251
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发表时间：
2015-07-01
期刊：
影响因子：
2.9
通讯作者：
Yamamoto, Kazuhide
中科院分区：
文献类型：
--
作者：
Iwamuro, Masaya;Okada, Hiroyuki;Yamamoto, Kazuhide
在累及肠道的滤泡性淋巴瘤患者中，小肠镜检查的重要性已得到强调。本研究的目的是确定日本患者群体中肠镜检查的现状，包括执行率和小肠病变的患病率。回顾性多中心调查17个机构收集了110例累及胃肠道的滤泡性淋巴瘤患者的病例资料。对肠镜检查结果进行回顾，为了确定影响肠镜检查成功率的潜在因素，将接受一次或多次肠镜检查的患者与未接受一次或多次肠镜检查的患者进行比较，包括患者性别、淋巴瘤诊断年龄、组织病理学分级、临床分期、初次诊断日期和该机构每年的肠镜检查量。共有34例患者（30.9%）接受了肠镜检查，其中24例（70.6%）表现为空肠和/或回肠受累。研究发现，近年来在超高容量机构（每年101例肠镜检查）诊断和治疗的患者中，更多的患者接受了肠镜检查。综上所述，虽然以累及肠道为表现的滤泡性淋巴瘤患者小肠病变发生率较高（70.6%），但肠镜检查表现率仅为30.9%，大部分患者未进行肠镜检查。在这些患者的初步诊断检查和随访期间，需要进一步的研究来确定肠镜检查的临床意义。
The importance of enteroscopy examinations to investigate the entire length of the small intestines has been emphasized in follicular lymphoma patients with intestinal involvement. The aim of the present study was to determine the current state of enteroscopy examinations, including the performance rate, and the prevalence of small intestinal lesions in a patient population in Japan. A retrospective multicenter survey of 17 institutions collected the case information of 110 follicular lymphoma patients with gastrointestinal involvement. The results of the enteroscopy examinations were reviewed, and in order to identify potential factors affecting the performance rate of enteroscopy, patient gender, age at lymphoma diagnosis, histopathological grade, clinical stage, the date of the initial diagnosis and the annual volume of enteroscopy at the institution were compared between the patients who underwent one or more enteroscopy procedures and the patients who did not undergo enteroscopy. A total of 34 patients (30.9%) underwent enteroscopy, and 24 of these (70.6%) presented with involvement in the jejunum and/or ileum. It was found that more patients diagnosed in recent years and more patients treated at an ultra-high volume institution (101 enteroscopy examinations/year) underwent an enteroscopy. In conclusion, although the prevalence of small intestinal lesions was high (70.6%) in the follicular lymphoma patients presenting with intestinal involvement, the performance rate of enteroscopy was only 30.9%, and thus the majority of the patients have not undergone enteroscopy examinations. Further investigation is required to define the clinical significance of enteroscopy at the initial diagnostic work-up and during the follow-up period of these patients.