Sleep dynamics: A self-organized critical system
Sleep dynamics: A self-organized critical system
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DOI：
10.1103/physreve.73.056127
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发表时间：
2006-05-01
影响因子：
2.4
通讯作者：
Salin, P. A.
中科院分区：
文献类型：
--
作者：
Comte, J. C.;Ravassard, P.;Salin, P. A.
在精神和神经疾病中，睡眠经常受到干扰。此外，最近对人类和动物的研究表明，睡眠在记忆过程中起着重要作用。反过来，学习任务后的睡眠动态被修改[Hubert， Nature (London) 02663,1 (2004), Peigneux, Neuron 44,535(2004)]。然而，人类和动物的睡眠分析往往局限于总睡眠时间和清醒时间的量化。这两个参数不能完全表征睡眠动力学。哺乳动物的睡眠呈现出一个复杂的组织，包括慢波睡眠（SWS）和矛盾睡眠（PS）的交替。此外，最近的研究表明，这些睡眠事件经常被微唤醒（没有觉醒）打断。我们在此详细分析了动物模型中警觉性状态交替机制所产生的基本睡眠特性。这些特性呈现出自组织临界系统特征，揭示了两个W、两个SWS和一个PS结构的存在，这些结构在砂桩中表现出临界状态。我们提出了一个基于几个相互作用的神经元群的睡眠动力学的理论模型。这种新的睡眠动力学模型呈现出与实验观察到的相同的特性，并解释了所收集数据的可变性。这项实验和理论研究表明，睡眠动力学与关键系统有几个共同的特征。
In psychiatric and neurological diseases, sleep is often perturbed. Moreover, recent works on humans and animals tend to show that sleep plays a strong role in memory processes. Reciprocally, sleep dynamics following a learning task is modified [Hubert , Nature (London) 02663, 1 (2004), Peigneux , Neuron 44, 535 (2004)]. However, sleep analysis in humans and animals is often limited to the total sleep and wake duration quantification. These two parameters are not fully able to characterize the sleep dynamics. In mammals sleep presents a complex organization with an alternation of slow wave sleep (SWS) and paradoxical sleep (PS) episodes. Moreover, it has been shown recently that these sleep episodes are frequently interrupted by micro-arousal (without awakening). We present here a detailed analysis of the basal sleep properties emerging from the mechanisms underlying the vigilance states alternation in an animal model. These properties present a self-organized critical system signature and reveal the existence of two W, two SWS, and a PS structure exhibiting a criticality as met in sand piles. We propose a theoretical model of the sleep dynamics based on several interacting neuronal populations. This new model of sleep dynamics presents the same properties as experimentally observed, and explains the variability of the collected data. This experimental and theoretical study suggests that sleep dynamics shares several common features with critical systems.