Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance?
Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance?
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DOI：
10.18632/oncotarget.2792
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发表时间：
2015-02-28
期刊：
影响因子：
--
通讯作者：
Cook RS
中科院分区：
文献类型：
--
作者：
Williams MM;Cook RS
细胞凋亡是由半胱天冬酶导致的细胞死亡，对乳房正常发育和体内平衡至关重要。促凋亡和抗凋亡信号在正常乳腺上皮细胞中受到严格调控。这种平衡失调是乳腺肿瘤发生所必需的，并增加了对治疗的获得性耐药性，包括分子靶向治疗、放疗和化疗。促凋亡或抗凋亡的Bcl-2家族成员相互作用以维持线粒体完整性并调节细胞凋亡。在抗凋亡的Bcl-2家族成员中，Mcl-1受到多种致癌信号通路的独特调控。本文将重点介绍Bcl-2家族蛋白在正常乳腺发育、乳腺肿瘤发生和乳腺癌治疗策略获得性耐药中的作用，同时强调Mcl-1是一个有希望改善乳腺癌肿瘤细胞杀伤的靶点。
Apoptosis, cell death executed by caspases, is essential to normal breast development and homeostasis. Pro-apoptotic and anti-apoptotic signals are tightly regulated in normal breast epithelial cells. Dysregulation of this balance is required for breast tumorigenesis and increases acquired resistance to treatments, including molecularly targeted therapies, radiation and chemotherapies. The pro-apoptotic or anti-apoptotic Bcl-2 family members interact with each other to maintain mitochondrial integrity and regulate cellular commitment to apoptosis. Among the anti-apoptotic Bcl-2 family members, Mcl-1 is uniquely regulated by numerous oncogenic signaling pathways. This review will focus on the role of Bcl-2 family proteins in normal breast development, breast tumorigenesis and acquired resistance to breast cancer treatment strategies, while highlighting Mcl-1 as a promising target to improve breast cancer tumor cell killing.
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影响因子：
11.2
作者：
Ding Q;Huo L;Yang JY;Xia W;Wei Y;Liao Y;Chang CJ;Yang Y;Lai CC;Lee DF;Yen CJ;Chen YJ;Hsu JM;Kuo HP;Lin CY;Tsai FJ;Li LY;Tsai CH;Hung MC
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作者：
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DOI：
10.1073/pnas.0701297104
发表时间：
2007-04-10
影响因子：
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影响因子：
37.3
作者：
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影响因子：
8
作者：
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通讯作者：
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