Meta-analysis of diffusion tensor imaging studies in schizophrenia
Meta-analysis of diffusion tensor imaging studies in schizophrenia
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DOI：
10.1016/j.schres.2008.11.021
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发表时间：
2009-03-01
影响因子：
4.5
通讯作者：
Bullmore, Edward T.
中科院分区：
文献类型：
--
作者：
Ellison-Wright, Ian;Bullmore, Edward T.
该研究的目的是确定精神分裂症患者是否存在一致的区域性白色物质变化。对精神分裂症（或相关疾病）患者与对照组的基于体素的弥散张量成像分数各向异性研究进行了系统检索。作者对分数各向异性差异的坐标进行了荟萃分析。对于荟萃分析，他们使用了与基因组扫描荟萃分析（GSMA）中使用的秩方法杂交的激活可能性估计（ALE）方法。该系统检测来自多个研究的坐标的三维连接，并允许根据样本量对研究进行加权。15篇文章被确定纳入荟萃分析，共包括407例精神分裂症患者和383例对照受试者。这些研究报告了精神分裂症患者在112个坐标处的各向异性分数降低，并且各向异性分数没有增加。在所有研究中，两个区域均出现显著减少：左额深部白色物质和左颞深部白色物质。第一个区域位于左额叶，由连接额叶、丘脑和扣带回的白色物质束穿过。第二个区域位于颞叶，白色物质束穿过该区域，将额叶、额叶、杏仁核、颞叶和枕叶连接起来。这表明，精神分裂症患者的两个白色物质束网络可能受到影响，它们之间连接的灰质区域可能会“断开”。(C)2008 Elsevier B.V.保留所有权利。
The objective of the study was to identify whether there are consistent regional white matter changes in schizophrenia. A systematic search was conducted for voxel-based diffusion tensor imaging fractional anisotropy Studies of patients with schizophrenia (or related disorders) in relation to comparison groups. The authors carried out meta-analysis of the co-ordinates of fractional anisotropy differences. For the meta-analysis they used the Activation Likelihood Estimation (ALE) method hybridized with the rank approach used in Genome Scan Meta-Analysis (GSMA). This system detects three-dimensional conjunctions of co-ordinates from multiple studies and permits the weighting of studies in relation to sample size. Fifteen articles were identified for inclusion in the meta-analysis, including a total of 407 patients with schizophrenia and 383 comparison subjects. The studies reported fractional anisotropy reductions at 112 co-ordinates in schizophrenia and no fractional anisotropy increases. Over all studies, significant reductions were present in two regions: the left frontal deep white matter and the left temporal deep white matter. The first region, in the left frontal lobe, is traversed by white matter tracts interconnecting the frontal lobe, thalamus and cingulate gyrus. The second region, in the temporal lobe, is traversed by white matter tracts interconnecting the frontal lobe, insula, hippocampus-amygdala, temporal and occipital lobe. This suggests that two networks of white matter tracts may be affected in schizophrenia, with the potential for 'disconnection' of the gray matter regions which they link. (C) 2008 Elsevier B.V. All rights reserved.