Human T lymphotropic virus type II infection and humoral responses to pneumococcal polysaccharide and tetanus toxoid vaccines.
Human T lymphotropic virus type II infection and humoral responses to pneumococcal polysaccharide and tetanus toxoid vaccines.
复制标题
人类 T 淋巴细胞病毒 II 型感染和对肺炎球菌多糖和破伤风类毒素疫苗的体液反应。
DOI：
10.1086/428505
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Murphy,EdwardL
中科院分区：
文献类型：
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作者：
Jarvis,GaryA;Janoff,EdwardN;Cheng,Hui;Devita,Deborah;Fasching,Claudine;McCulloch,CharlesE;Murphy,EdwardL
人类嗜T淋巴细胞病毒II型（HTLV-II）的感染与细菌性肺炎的发病率增加有关。为了确定HTLV-II感染是否与受损的体液免疫应答相关，我们用23价肺炎球菌多糖和破伤风类毒素疫苗免疫了一组HTLV-II感染受试者和匹配的未感染对照受试者。肺炎球菌多糖疫苗在免疫后1个月和6个月在两组中引起了针对所有5种血清型的IgG浓度的相当和显著的增加。抗囊膜IgG的亲和力和调理吞噬功能相似。两组中破伤风类毒素特异性IgG的浓度也随时间显著增加。因此，HTLV-II感染者对潜在的保护性多糖和蛋白质疫苗产生强烈的体液应答
Infection with human T lymphotropic virus type II (HTLV-II) has been linked to an increased incidence of bacterial pneumonia. To determine whether HTLV-II infection is associated with impaired humoral immune responses, we immunized a cohort of HTLV-II–infected subjects and matched uninfected control subjects with 23-valent pneumococcal polysaccharide and tetanus toxoid vaccines. The pneumococcal polysaccharide vaccine elicited comparable and significant increases in concentrations of IgG against all 5 serotypes tested at 1 and 6 months after immunization in both groups. The avidity and opsonophagocytic functions of the anticapsular IgG were similar. The concentrations of tetanus toxoid–specific IgG also increased comparably and significantly over time in both groups. Thus, HTLV-II–infected persons develop robust humoral responses to potentially protective polysaccharide and protein vaccines