Filament organization and contractile function in vertebrate smooth muscle.
Filament organization and contractile function in vertebrate smooth muscle.
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脊椎动物平滑肌的丝组织和收缩功能。
DOI：
10.1146/annurev.ph.41.030179.003513
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发表时间：
1979
影响因子：
18.2
通讯作者：
R. A. Murphy
中科院分区：
文献类型：
--
作者：
R. A. Murphy
在肌肉收缩的滑丝模型中，肌动蛋白和肌球蛋白以不同的结构组织，它们之间的循环相互作用通过两种类型的丝之间的平移运动产生力和缩短。由一个收缩单元（横纹肌中的肌节）产生的力是由所有相互作用的平行耦合的部位产生的力的总和。结构和力学数据的综合证实了横纹肌的这种机制[(24)；也见本卷中的Tregear & Marston]。本章回顾了已经提出的脊椎动物平滑肌收缩系统的结构模型。简要讨论了脊椎动物平滑肌结构满足滑丝模型要求的证据。描述了几种类型的模型，显示出适应已知事实的希望；并指出了判别各种假设之前必须获得的关键数据。
In a sliding-filament model of muscle contraction, actin and myosin are organized in distinct structures, and cyclic interactions between them gen erate force and shortening by a translational movement between the two types of filaments. Force developed by a contractile unit (the sarcomere in striated muscle) is the sum of the forces generated by all the interacting sites coupled in parallel. Such a mechanism was confirmed for striated muscles by a synthesis of structural and mechanical data [(24); see also Tregear & Marston in the present volume]. This chapter reviews structural models that have been proposed for the contractile system of vertebrate smooth muscle. Evidence for structures in vertebrate smooth muscle that meet requirements of a sliding-filament model is discussed briefly. Several types of models are described that show promise of accommodating the known facts; and key data that must be obtained before various hypotheses can be discriminated are noted.