Well-Defined Gold Nanorod/Polymer Hybrid Coating with Inherent Antifouling and Photothermal Bactericidal Properties for Treating Infected Hernia
Well-Defined Gold Nanorod/Polymer Hybrid Coating with Inherent Antifouling and Photothermal Bactericidal Properties for Treating Infected Hernia
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明确的金纳米棒/聚合物混合涂层具有固有的防污和光热杀菌特性，可用于治疗感染性疝气
DOI：
10.1021/acsnano.9b09282
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发表时间：
2020
期刊：
影响因子：
17.1
通讯作者：
Fu-Jian Xu
中科院分区：
文献类型：
--
作者：
Yu-Qing Zhao;Yujie Sun;Yidan Zhang;Xiaokang Ding;Nana Zhao;Bingran Yu;Hong Zhao;Shun Duan;Fu-Jian Xu
生物医疗器械相关性感染（BAI）是现代临床医学面临的重大挑战。因此，开发高效的抗菌材料对提高医疗水平和人民健康具有重要意义。在目前的工作中，我们开发了一种多功能抗菌应用的表面功能化的策略。基于由金纳米棒（Au NRs）和聚乙二醇（PEG）组成的近红外（NIR）响应性有机/无机杂化涂层，制备了一种功能化聚氨酯（PU）表面（PU-Au-PEG）。PU-Au-PEG在808 nm近红外辐射下表现出良好的光热杀菌性能，尤其是对多重耐药菌的杀菌效果更好。此外，PU-Au-PEG可以长期抑制生物膜的形成。细胞毒性试验和溶血试验也证明了PU-Au-PEG的生物相容性。首次通过皮下埋植动物模型验证了其体内光热抗菌特性。然后，使用感染的疝模型研究了在临床情况下的抗感染性能。动物实验结果表明PU-Au-PEG具有良好的体内抗感染作用。本工作为开发多功能生物医学器件提供了一种简便可行的方法。
Biomedical device-associated infection (BAI) is a great challenge in modern clinical medicine. Therefore, developing efficient antibacterial materials is significantly important and meaningful for the improvement of medical treatment and people’s health. In the present work, we developed a strategy of surface functionalization for multifunctional antibacterial applications. A functionalized polyurethane (PU, a widely used biomedical material for hernia repairing) surface (PU-Au-PEG) with inherent antifouling and photothermal bactericidal properties was readily prepared based on a near-infrared (NIR)-responsive organic/inorganic hybrid coating which consists of gold nanorods (Au NRs) and polyethylene glycol (PEG). The PU-Au-PEG showed a high efficiency to resist adhesion of bacteria and exhibited effective photothermal bactericidal properties under 808 nm NIR irradiation, especially against multidrug-resistant bacteria. Furthermore, the PU-Au-PEG could inhibit biofilm formation long term. The biocompatibility of PU-Au-PEG was also proved by cytotoxicity and hemolysis tests. Thein vivophotothermal antibacterial properties were first verified by a subcutaneous implantation animal model. Then, the anti-infection performance in a clinical scenario was studied with an infected hernia model. The results of animal experiment studies demonstrated excellentin vivoanti-infection performances of PU-Au-PEG. The present work provides a facile and promising approach to develop multifunctional biomedical devices.