Influence of duration of type 1 diabetes on long-term pancreatic transplant outcomes
Influence of duration of type 1 diabetes on long-term pancreatic transplant outcomes
复制标题
1型糖尿病病程对长期胰腺移植结果的影响
DOI：
10.1002/jhbp.677
复制
发表时间：
2019-11-02
影响因子：
3
通讯作者：
Hu, Zhenhua
中科院分区：
文献类型：
--
作者：
Zhou, Jie;Dong, Yinlei;Hu, Zhenhua
背景：目前还没有多中心研究糖尿病病程对胰腺移植结果的影响。我们的研究旨在确定1型糖尿病病程如何影响胰腺移植物的存活率。方法2006-2015年期间接受胰腺移植的8，139例患者的数据来自移植受体科学登记数据库。根据糖尿病病程将患者分为两组：S组（糖尿病20年）。结果与S组相比，L组年龄偏大、男性、体重指数偏高、肾移植后接受胰腺移植（PAK）的患者多为白色人。两组患者生存率无显著差异，但L组胰腺生存率更好（风险比0.88; P = 0.012）。单纯胰腺移植和胰肾联合移植（SPK）中，L组胰腺存活率优于S组。两组PAK移植物存活率无显著差异。糖尿病病程是SPK患者移植物存活的独立预测因子（风险比0.86; P = 0.012）。结论糖尿病病程对患者生存无影响。然而，长期的1型糖尿病似乎对胰腺移植物丢失有保护作用。
Background There are no multicenter studies on the influence of diabetes duration on pancreatic transplant outcomes. Our study aimed to determine how type 1 diabetes duration influenced survival of pancreatic grafts. Methods The data of 8,139 patients who received pancreas transplants during 2006-2015 were extracted from the Scientific Registry of Transplant Recipients database. Patients were separated into two groups according to duration of diabetes: S group (diabetes 20 years). Results Compared to S group, L group were older and prone to be male, to have higher body mass index, to receive pancreas after kidney transplantation (PAK), and to be White. Patient survival was not significantly different between the two groups, but pancreatic survival was better in the L group (hazard ratio 0.88; P = 0.012). Pancreatic survival of L group was better than S group in pancreas transplant alone and simultaneous pancreas-kidney transplantation (SPK). Graft survival was not significant different between the two groups in PAK. Diabetes duration was an independent predictor of graft survival in SPK patients (hazard ratio 0.86; P = 0.012). Conclusions Diabetes duration has no influence on patient survival. However, long duration of type 1 diabetes mellitus appears to be protective against pancreatic graft loss.