Dementia prevalence, a contextual factor associated with SARS-CoV-2 in veterans affairs community living centers.
Dementia prevalence, a contextual factor associated with SARS-CoV-2 in veterans affairs community living centers.
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DOI：
10.1111/jgs.17945
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发表时间：
2022-10
影响因子：
6.3
通讯作者：
Rudolph, James L.
中科院分区：
文献类型：
--
作者：
Bayer, Thomas A.;DeVone, Frank;McConeghy, Kevin W.;Halladay, Christopher W.;Quach, Lien;Rajan, Ashna;Elhamamsy, Salaheldin;Cadieux, Marilyne;Singh, Mriganka;Sachar, Moniyka;Nanda, Aman;Gravenstein, Stefan;Rudolph, James L.
阿尔茨海默病和相关痴呆症(ADRD)通过影响养老院居民及其照顾者的行为，影响疗养院对SARS冠状病毒2(SARS-CoV-2)的诊断和感染控制。卫生系统数据显示，ADRD与SARS-CoV-2之间存在关联。这种关联是否存在于NH人群中仍不得而知。患有ADRD的居民中SARS-CoV-2风险的增加如何影响更多的NH人口也尚不清楚。这项回顾性队列研究使用了从2020年3月1日至2020年12月13日居住在133个退伍军人事务社区生活中心(CLC)和15个脊髓损伤单元的退伍军人的电子健康记录数据。我们在每个居民的SARS-CoV-2指数检测日期前12个月使用诊断代码来测量ADRD。我们使用泊松回归来确定设施ADRD患病率最高的四分位数与最低的四分位数的SARS-CoV-2的相对风险，按个体ADRD状态分层，并调整协变量，在有和没有随机截距的情况下考虑设施聚集。在整个研究期间，15,043名居民居住在CLC，1,952名(13.0%)患有SARS-CoV-2，8,067名(53.6%)患有ADRD。痴呆症患病率最高的设施与最低的设施相比，SARS-CoV-2的风险估计增加了60%(相对风险，1.6[95%可信区间0.95，2.7])。在ADRD流行率较高的机构中，CLC居民感染SARS-CoV-2的可能性更大。除ADRD流行之外的其他设施特征可能解释了这种联系。
Alzheimer’s disease and related dementias (ADRD) impact the diagnosis and infection control of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in nursing homes (NH) by influencing the behavior of residents and their caregivers. Health system data show an association between ADRD and SARS-CoV-2. Whether this association is present in NH populations remains unknown. How increased SARS-CoV-2 risk among residents with ADRD impacts the greater NH population also remains unknown. This retrospective cohort study used electronic health record data on Veterans residing in 133 Veterans Affairs Community Living Centers (CLC) and 15 spinal cord injury units from March 1, 2020 to December 13, 2020. We measured ADRD using diagnostic codes 12 months prior to an index SARS-CoV-2 test date for each resident. We used Poisson regression to determine the relative risk of SARS-CoV-2 for the highest quartile of facility ADRD prevalence versus the lowest, stratifying by individual ADRD status, and adjusting for covariates, with and without a random intercept to account for facility clustering. Across the study period, 15,043 residents resided in CLCs, 1,952 (13.0%) had SARS-CoV-2, and 8,067 (53.6%) had ADRD. There was an estimated 60% increased risk of SARS-CoV-2 in facilities with highest dementia prevalence versus lowest (Relative Risk, 1.6 [95% Confidence Interval 0.95, 2.7]). CLC residents had a greater likelihood of SARS-CoV-2 infection in facilities with greater ADRD prevalence. Facility characteristics other than ADRD prevalence may account for this association.
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影响因子：
6.3
作者：
Lipsitz LA;Lujan AM;Dufour A;Abrahams G;Magliozzi H;Herndon L;Dar M
通讯作者：
Dar M
影响因子：
13.8
作者：
Mehta HB;Li S;Goodwin JS
通讯作者：
Goodwin JS
影响因子：
4
作者：
Sachar M;Bayer T;DeVone F;Halladay C;McConeghy K;Elhamamsy S;Rajan A;Cadieux M;Singh M;Nanda A;Rudolph JL;McNicoll L;Cizginer S;Gravenstein S
通讯作者：
Gravenstein S
DOI：
10.1016/j.jamda.2020.06.009
发表时间：
2020-07-01
影响因子：
7.6
作者：
Rudolph, James L.;Halladay, Christopher W.;Gravenstein, Stefan
通讯作者：
Gravenstein, Stefan
DOI：
10.1093/gerona/glab355
发表时间：
2022-07-05
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Dufour AB;Kosar C;Mor V;Lipsitz LA
通讯作者：
Lipsitz LA