Prevention and treatment of cytomegalovirus infection.
Prevention and treatment of cytomegalovirus infection.
复制标题
预防和治疗巨细胞病毒感染。
DOI：
10.1146/annurev.me.42.020191.001143
复制
发表时间：
1991
影响因子：
10.5
通讯作者：
Meyers,JD
中科院分区：
文献类型：
--
作者：
Meyers,JD
巨细胞病毒（CMV）虽然在正常人中是一种罕见的症状性感染，但在免疫功能低下的宿主中却越来越重要。现在有更昔洛韦的有效治疗；foscarnet提供了一种可能的替代方案，特别是对于感染了更昔洛韦耐药巨细胞病毒菌株的患者。原发性巨细胞病毒感染可通过对献血者（和器官）进行血清学筛查来预防。预防输血相关巨细胞病毒感染的另一种方法是滤过白细胞消耗。免疫球蛋白免疫预防仍有争议，但可能有效改善同种异体肾移植患者的疾病。无环鸟苷在抑制血清学阳性患者感染方面部分有效，但更昔洛韦和氟膦酸钠在这方面更有希望。
Although a rare cause of symptomatic infection in normal persons, cytomegalovirus (CMV) is of increasing importance in the immunocompromised host. Effective treatment is now available with ganciclovir; foscarnet offers a possible alternative, especially for patients infected with ganciclovir-resistant CMV strains. Primary CMV infection can be prevented by serologic screening of blood (and organ) donors. An alternative approach for prevention of transfusion-associated CMV infection is leukocyte depletion by filtration. Immunoglobulin immunoprophylaxis remains controversial but may be effective in ameliorating disease in renal allograft patients. Acyclovir is partially effective in suppressing infection in already seropositive patients, but ganciclovir and foscarnet offer more promise for this purpose.