ESTRADIOL ENHANCES BRAIN GLUCOSE-UPTAKE IN OVARIECTOMIZED RATS
ESTRADIOL ENHANCES BRAIN GLUCOSE-UPTAKE IN OVARIECTOMIZED RATS
复制标题
DOI：
10.1016/0361-9230(94)00208-i
复制
发表时间：
1995-01-01
影响因子：
3.8
通讯作者：
SIMPKINS, JW
中科院分区：
文献类型：
--
作者：
BISHOP, J;SIMPKINS, JW
本研究旨在探讨17 β -雌二醇苯甲酸酯（E(2)B）对大鼠脑葡萄糖摄取及血脑屏障转运的影响，对E(2)B对中枢神经系统（CNS）葡萄糖摄取的影响进行了时间和剂量反应评价，在评价前2 ~ 24 h皮下注射E(2)B，剂量范围为1 ~ 100 μ g/kg体重。在4小时的时间点和10 μ g/kg的剂量下，E(2)B产生了最广泛的葡萄糖摄取增加，与油处理的对照组相比，6个区域对E(2)B有反应，葡萄糖摄取升高高达120%，然后我们评估了E(2)B对血脑屏障中葡萄糖运输的影响，E(2)B显著增加了40%的标记糖通过血脑屏障的提取，而不影响内标的提取。总的来说，这些研究表明，生理水平的雌二醇（E(2)）可能在调节脑葡萄糖稳态中发挥重要作用。
This study was designed to investigate the effects of 17 beta-estradiol benzoate (E(2)B) on brain glucose uptake and transport across the blood-brain barrier (BBB), Both a time- and dose-response evaluation of the effect of E(2)B on glucose uptake in the central nervous system (CNS) were conducted, E(2)B, in doses ranging from 1 to 100 mu g/kg body weight, was injected subcutaneously at 2 to 24 h prior to evaluation, The 4-h time point and 10 mu g/kg dose of E(2)B produced the most widespread increases in glucose uptake, Six regions responded to E(2)B with elevated glucose uptake by as much as 120% when compared to oil-treated controls, We then evaluated the effects of E(2)B on transport of glucose across the BBB, E(2)B significantly increased the extraction of labeled sugar across the BBB by 40% without affecting extraction of the internal standard. Collectively, these studies indicate that physiological levels of estradiol (E(2)) may play an important role in modulating cerebral glucose homeostasis.