A BEN-domain protein and polycomb complex work coordinately to regulate transcription
A BEN-domain protein and polycomb complex work coordinately to regulate transcription
复制标题
DOI：
10.1080/21541264.2022.2105128
复制
发表时间：
2022-07-29
影响因子：
3.6
通讯作者：
Prasanth, Supriya G.
中科院分区：
文献类型：
--
作者：
Kurniawan, Fredy;Prasanth, Supriya G.
转录调控是控制多能性和分化的重要机制。转录因子通过与染色质调节因子的协同作用决定细胞的命运。我们最近证明，BEND 3（BANP，E5 R和Nac 1结构域）蛋白通过调节启动子处的染色质结构来调节分化相关基因的表达。我们强调了BEND 3与polycomb抑制复合物在协调转录抑制方面的合作，并提出了一个模型，强调了BEND 3-PRC 2轴在基因调控和染色质组织中的相关性。
Transcription regulation is an important mechanism that controls pluripotency and differentiation. Transcription factors dictate cell fate decisions by functioning cooperatively with chromatin regulators. We have recently demonstrated that BEND3 (BANP, E5R and Nac1 domain) protein regulates the expression of differentiation-associated genes by modulating the chromatin architecture at promoters. We highlight the collaboration of BEND3 with the polycomb repressive complex in coordinating transcription repression and propose a model highlighting the relevance of the BEND3-PRC2 axis in gene regulation and chromatin organization.