Novel microreactors for functional polymer beads
Novel microreactors for functional polymer beads
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DOI：
10.1016/j.cej.2003.11.019
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发表时间：
2004-08-01
影响因子：
15.1
通讯作者：
Higuchi, T
中科院分区：
文献类型：
--
作者：
Nisisako, T;Torii, T;Higuchi, T
描述了一种制备多个相同尺寸的聚合物微球的新技术。在T形微通道中制备丙烯酸单体的单分散液滴悬浮液，并通过随后的聚合产生精确相同尺寸的颗粒。通过改变微流体装置中的流动条件，液滴/颗粒尺寸在直径30-120 μ m的范围内灵活地变化。所得产品的变异系数（CV）低于2%。流动参数图显示了一个清晰的区域，其中成功地形成了单一尺寸的液滴。此外，使用另一种微流体装置，设计了直径为90-190 μ m的半球形着色丙烯酸微球，其变异系数小于1%。(C)2003 Elsevier B. V.保留所有权利。
A novel technique is described for preparing multiple polymeric microspheres of the same size. A monodisperse droplet suspension of an acrylic monomer was prepared in a T-shaped microchannel, and particles of accurately the same size were produced by subsequent polymerization. The droplet/particle size was varied flexibly in the range of diameters 30-120 mum by changing the flow conditions in a microfluidic device. The resulting products have a coefficient of variation (CV) below 2%. A diagram of the flow parameters showed a clear region in which monosized drops were formed successfully. Furthermore, using another microfluidic device, hemi spherically colored acrylic microspheres of 90-190 mum in diameter were engineered with a coefficient of variation of less than 1%. (C) 2003 Elsevier B.V. All rights reserved.