Resting state brain activity in patients with migraine: a magnetoencephalography study.
Resting state brain activity in patients with migraine: a magnetoencephalography study.
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偏头痛患者静息状态下的大脑活动：脑磁图研究
DOI：
10.1186/s10194-015-0525-5
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Wang, Xiaoshan
中科院分区：
文献类型：
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作者：
Liu, Hongxing;Ge, Huaiting;Wang, Xiaoshan
背景偏头痛研究的最新进展表明，大脑皮层在偏头痛的发病机制中起主要作用。由于偏头痛的异常脑活动，可以非侵入性检测脑磁图（MEG），本研究的目的是探讨休息状态偏头痛和控制及其相关的临床characteristics.MethodsTwenty-two受试者与急性偏头痛和22个年龄和性别匹配的控制之间的皮层活动差异进行了研究，使用脑磁图。在头痛发作期间记录了120秒的MEG记录。结果与对照组相比，偏头痛患者的脑电活动在两个频率范围（55-90 Hz，p < 0.001）和（90-200 Hz，p < 0.004）均有显著性差异。偏头痛组与正常对照组在各频率范围内的功率值无显著性差异（p > 0.05）。所有的临床特征没有显着的相关性与异常的大脑activity.ConclusionsThe结果表明，偏头痛受试者在静息状态下有显着异常发作的大脑活动，可以测量与神经磁成像技术。这些发现可能有助于开发新的治疗策略，通过改变皮质兴奋性与TMS和其他药物在未来的偏头痛治疗。
BackgroundRecent advances in migraine research have shown that the cerebral cortex serves a primary role in the pathogenesis of migraine. Since aberrant brain activity in migraine can be noninvasively detected with magnetoencephalography (MEG), The object of this study was to investigate the resting state cortical activity differences between migraineurs and controls and its related clinical characteristics.MethodsTwenty-two subjects with an acute migraine and twenty-two age- and gender-matched controls were studied using MEG. MEG recordings were recorded 120 seconds during the headache attack. Analyze MEG signals from low (1–4 Hz) to high (200–1000 Hz)-frequency ranges.ResultsIn comparison with the controls, brain activity in migraine subjects was significantly different from that of the controls both in two frequency ranges (55–90 Hz, p < 0.001) and (90–200 Hz, p < 0.004). But the power value showed no significantly differences between control and migraines in all frequency ranges (p > 0.05). All the clinical characteristics had no significant correlation with aberrant brain activity.ConclusionsThe results demonstrated that migraine subjects in resting state had significantly aberrant ictal brain activity that can be measured with neuromagnetic imaging techniques. The findings may facilitate the development of new therapeutic strategies in migraine treatment via alterations in cortical excitability with TMS and other medications in the future.