Effects of operating conditions on the performance of cross-flow microfiltration of fine particle/protein binary suspension
Effects of operating conditions on the performance of cross-flow microfiltration of fine particle/protein binary suspension
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DOI：
10.1016/j.memsci.2005.05.033
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发表时间：
2006-04
影响因子：
9.5
通讯作者：
K. Hwang;Fu-Yuan Chou;K. Tung
中科院分区：
文献类型：
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作者：
K. Hwang;Fu-Yuan Chou;K. Tung
研究了错流微滤超细颗粒/蛋白质二元悬浮液的操作条件，如错流速度、过滤压力和悬浮液的pH值对过滤速度、滤饼性质和蛋白质截留率的影响。用聚甲基丙烯酸甲酯(PMMA)亚微米粒子和牛血清白蛋白(BSA)制备的二元悬浮液进行了实验。对不同操作条件下滤饼的质量、厚度、孔隙率和比过滤阻力进行了测量和讨论。结果表明，滤饼性质是决定滤速和BSA截留率的重要因素。过滤速率随着错流速度和过滤压力的增大而增大，最大过滤速率出现在pH为6.7时。建立了一个流体力学模型来估算不同条件下的滤饼性质和滤失率。计算结果与实验数据吻合较好。此外，BSA截留率随错流速度的增加而增加，但随过滤压力变化不大。在一定的过滤压力和错流速度下，pH为6.7的BSA截留率高于其它pH值。标准捕集方程用于关联BSA截留率和滤饼厚度。得到的筛分参数在给定的错流速度下保持不变。
The effects of operating conditions, such as cross-flow velocity, filtration pressure and the pH of suspension, on the filtration rate, the cake properties and the protein rejection in a cross-flow microfiltration of fine particle/protein binary suspensions are studied. Experiments are carried out using the binary suspensions prepared by polymethyl methacrylate (PMMA) submicron particles and bovine serum albumin (BSA) proteins. The mass, thickness, porosity and specific filtration resistance of the filter cakes under various operating conditions are measured and well discussed. The results show that the cake properties are important factors in determining filtration rate and BSA rejection. The filtration rate increases with increasing cross-flow velocity and filtration pressure, while the highest filtration rate occurs at pH 6.7. A hydrodynamic model is derived to estimate the cake properties and filtration rates under various conditions. The calculated results are in good agreement with the experimental data. In addition, the BSA rejection increases with increasing cross-flow velocity; but a trivial variation with filtration pressure is found. For a given filtration pressure and cross-flow velocity, the BSA rejection at pH 6.7 is higher than those at the other pH values. The standard capture equation is used to relate the BSA rejection and the cake thickness. The obtained screen parameter remains constant under a given cross-flow velocity.