Bidirectional plasticity in fast-spiking GABA circuits by visual experience
Bidirectional plasticity in fast-spiking GABA circuits by visual experience
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DOI：
10.1038/nature08485
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发表时间：
2009-11-12
期刊：
影响因子：
64.8
通讯作者：
Hensch, Takao K.
中科院分区：
文献类型：
--
作者：
Yazaki-Sugiyama, Yoko;Kang, Siu;Hensch, Takao K.
大脑中依赖经验的可塑性需要平衡兴奋抑制1。在复杂的新皮层网络中，单个回路元件如何对可塑性结果做出贡献尚不清楚。在这里，我们报告了一个眼优势可塑性的细胞内分析-在生命早期丧失视力的眼睛的敏锐度和皮质反应性的丧失2，3。与典型的渐进性细胞偏向不同，体内快速发放细胞的直接记录揭示了一个违反直觉的最初转向被遮挡的眼睛，随后是对睁开眼睛的后期偏好，这与这些神经元的发放时间依赖性可塑性规则一致。细胞内药理学证实，GABA（c-氨基丁酸）的动态开关影响锥体细胞剥夺后，只有在幼年小鼠。总之，这些结果表明，最初的双眼GABA回路的双向募集可能有助于发育中的视觉皮层的经验依赖性可塑性。
Experience-dependent plasticity in the brain requires balancedexcitation-inhibition1. How individual circuit elements contributeto plasticity outcome in complex neocortical networks remainsunknown. Here we report an intracellular analysis of ocular dominanceplasticity-the loss of acuity and cortical responsiveness foran eye deprived of vision in early life2,3. Unlike the typical progressiveloss of pyramidal-cell bias, direct recording from fast-spikingcells in vivo reveals a counterintuitive initial shift towards theoccluded eye followed by a late preference for the open eye, consistentwith a spike-timing-dependent plasticity rule for these inhibitoryneurons. Intracellular pharmacology confirms a dynamicswitch of GABA (c-aminobutyric acid) impact to pyramidal cellsfollowing deprivation in juvenile mice only. Together these resultssuggest that the bidirectional recruitment of an initially binocularGABA circuit may contribute to experience-dependent plasticity inthe developing visual cortex.