Novel pressure-sensing skin for detecting impending tissue damage during neuroendoscopy.
Novel pressure-sensing skin for detecting impending tissue damage during neuroendoscopy.
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DOI：
10.3171/2013.9.peds12595
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
P. Codd;Arabagi Veaceslav;A. Gosline;P. Dupont
中科院分区：
文献类型：
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作者：
P. Codd;Arabagi Veaceslav;A. Gosline;P. Dupont
视神经内镜在微创神经外科手术中发挥着越来越重要的作用。来自内窥镜头端的视觉反馈有助于外科医生防止不必要的组织接触。然而，目前无法获得关于近端内窥镜组件造成的组织变形和创伤的关键反馈。沿着内窥镜长度的力反馈系统可通过警告即将发生的损伤提供显著的临床受益。作者制造并测试了一种新型压力传感聚合物皮肤，用于颅内内窥镜检查期间的压力反馈。方法在硅晶片上采用光刻工艺制作80 μ m高的挤压物图案，作为传感器阵列的阳模。将聚二甲基硅氧烷聚合物薄层模制到这些特征上。将聚合物从晶片上脱模并用另一聚合物层密封，得到微通道。这些微通道填充有导电液体金属并连接到记录硬件。螺旋通道图案被设计为创建3 × 3阵列的压力传感器垫，其缠绕在标准神经内窥镜手术鞘周围。来自压缩传感器阵列的压力读数被转换成颜色编码的图形用户界面。进行了标定实验，并通过脑皮层压缩实验对传感器进行了评价。结果传感内窥镜手术鞘成功校准，以检测和显示与正常和组织威胁性按压一致的范围内的压力。结论：神经内窥镜医师的力反馈机制在当代内窥镜中严重缺乏。作者设计了一种压力感应皮肤技术，用于改善内窥镜检查期间的压力反馈，作为最大限度地减少内窥镜检查期间附带组织损伤的一种方法。
OBJECT Endoscopy plays an increasingly important role in minimally invasive neurosurgery. Visual feedback from the endoscope tip helps the surgeon prevent unwanted tissue contact. However, critical feedback regarding tissue deformation and trauma from proximal endoscope components is currently unavailable. A system for force feedback along the endoscope length could provide significant clinical benefit by warning of impending damage. The authors manufactured and tested a novel pressure-sensing polymer skin for use in pressure feedback during intracranial endoscopy. METHODS A photolithography process on a silicon wafer was used to produce a pattern of 80-μm-tall extrusions to serve as a positive mold for the sensor array. A thin layer of polydimethylsiloxane polymer was molded onto these features. Demolding the polymer from the wafer and sealing with another polymer layer resulted in microchannels. These microchannels were filled with a conductive liquid metal and connected to recording hardware. Spiral channel patterns were designed to create a 3 × 3 array of pressure-sensor pads, which were wrapped around a standard neuroendoscope operating sheath. Pressure readings from the compressed sensor array were translated into a color-coded graphic user interface. Calibration experiments were conducted, and the sensor was evaluated through cortical compression tests on explanted ovine brain. RESULTS The sensing endoscope operating sheath was successfully calibrated to detect and display pressures within a range consistent with normal and tissue-threatening compressions. CONCLUSIONS Force-feedback mechanisms for the neuroendoscopist are critically lacking with contemporary endoscopes. The authors designed a pressure-sensing skin technology for improved pressure feedback during endoscopy as a means for minimizing collateral tissue damage during endoscopy.