G-protein gamma subunit GNG11 strongly regulates cellular senescence.
G-protein gamma subunit GNG11 strongly regulates cellular senescence.
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DOI：
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发表时间：
2006
影响因子：
3.1
通讯作者：
M. Hossain;Risa Sakemura;M. Fujii;D. Ayusawa
中科院分区：
文献类型：
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作者：
M. Hossain;Risa Sakemura;M. Fujii;D. Ayusawa
GNG11是异聚g蛋白γ亚基家族的成员，但其功能完全未知。在这里，我们成功地表征了它在细胞衰老中的特定作用。我们发现GNG11过表达可立即诱导正常人成纤维细胞衰老，通过反义cDNA下调其表达可延长成纤维细胞的寿命。令人惊讶的是，这种基因被诱导衰老的药物如氢氧氧(H（2)O(2)）迅速诱导。此外，GNG11的过表达激活了MAP激酶家族的ERK1/2，但没有激活Ras。总之，这些结果表明GNG11介导的一种新的衰老途径响应环境因素。
GNG11 is a member of the gamma subunit family of heteromeric G-protein, but its function is entirely unknown. Here, we successfully characterized its specific role in cellular senescence. We have found that overexpression of GNG11 immediately induces cellular senescence in normal human fibroblasts, and its down-regulation by antisense cDNA extends their lifespan. Surprisingly, this gene is very rapidly induced by senescence-inducing agents such as H(2)O(2). Furthermore, overexpression of GNG11 activated ERK1/2 of the MAP kinase family, but did not Ras. Collectively, these results suggest a novel senescence pathway mediated by GNG11 in response to environmental cues.