IRON METABOLISM - IRON STORES IN MAN AS MEASURED BY PHLEBOTOMY
IRON METABOLISM - IRON STORES IN MAN AS MEASURED BY PHLEBOTOMY
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DOI：
10.1172/jci102639
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发表时间：
1952-01-01
影响因子：
15.9
通讯作者：
FINCH, CA
中科院分区：
文献类型：
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作者：
HASKINS, D;STEVENS, AR;FINCH, CA
人体中铁的储存量是通过 detn 来测量的。重复放血后，Fe 被动员用于红细胞生成。正常年轻男性为1200至1500毫克。可以在 4 个月内动员起来；这实际上代表了可用铁的全部储存，这通过出血期末期的造血迟缓表明。血液水平正常但有重复献血史的个体只能动员 200 毫克。铁储存量增加的受试者、血色素沉着症患者及其亲属，以及服用补充口服铁的正常受试者，能够调动更多的铁量。放血前长期补充铁饲喂对正常情况下铁储备的大小几乎没有影响。一旦铁储备耗尽，它们就会通过正常饮食或补充口服铁来缓慢重建。
Fe stores in man were measured by the detn. of Fe mobilized for red cell production following repeated phlebotomy. In normal young men, 1200 to 1500 mg. could be mobilized in 4 mos.; that this represented virtually the entire store of available Fe was indicated by retarded hematopoiesis toward the end of the bleeding period. Individuals with normal blood levels, but with histories of repeated blood donations, were able to mobilize only 200 mg. Subjects with increased Fe stored, patients with hemochromatosis and their relatives, and normal subjects taking supplementary oral Fe, were able to mobilize far greater amts. Prolonged supplementary Fe feeding prior to the phlebotomies had little effect on the size of the stores in the normal. Once Fe stores had been depleted, they were rebuilt slowly, either from a normal diet or from supplementary oral Fe.