Temperature distribution in selective laser-tissue interaction
Temperature distribution in selective laser-tissue interaction
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DOI：
10.1117/1.2204615
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发表时间：
2006-05-01
影响因子：
3.5
通讯作者：
Chen, Wei R.
中科院分区：
文献类型：
--
作者：
Crochet, Jared J.;Gnyawali, Surya C.;Chen, Wei R.
使用染料增强的选择性光热相互作用已被证明在最小化周围组织损伤和向靶组织递送能量方面是有效的。在激光照射过程中，靶组织及其周围组织中的光子吸收和热能扩散过程是至关重要的。这些信息允许选择适当的操作参数，例如染料浓度、激光功率和曝光时间，以获得最佳治疗效果。结合能量吸收的MonteCarlo方法和热扩散的有限差分方法，得到了染料增强激光光热相互作用中靶组织和周围组织的温度分布。在模拟中使用不同的组织配置和染料增强，并且还使用不同的入射光束尺寸来确定用于各种组织配置的最佳光束尺寸。我们的结果表明，在这项研究中开发的算法可以预测激光照射的热结果。我们的模拟表明，适当的吸收增强的目标组织，在目标组织和周围组织的温度可以有效地控制。该方法可用于使用激光光热相互作用的病变治疗的优化。它还可以为癌症治疗中的激光免疫疗法提供指导，因为免疫反应被认为与组织温度变化有关。(c)2006年，由光学仪器工程师协会（Society of Photo-Optical Instrumentation Engineers）主办。
Selective photothermal interaction using dye enhancement has proven to be effective in minimizing surrounding tissue damage and delivering energy to target tissue. During laser irradiation, the process of photon absorption and thermal energy diffusion in the target tissue and its surrounding tissue are crucial. Such information allows the selection of proper operating parameters such as dye concentrations, laser power, and exposure time for optimal therapeutic effect. Combining the Monte Carlo method for energy absorption and the finite difference method for heat diffusion, the temperature distributions in target tissue and surrounding tissue in dye enhanced laser photothermal interaction are obtained. Different tissue configurations and dye enhancement are used in the simulation, and different incident beam sizes are also used to determine optimum beam sizes for various tissue configurations. Our results show that the algorithm developed in this study could predict the thermal outcome of laser irradiation. Our simulation indicates that with appropriate absorption enhancement of the target tissue, the temperature in the target tissue and in the surrounding tissue can be effectively controlled. This method can be used for optimization of lesion treatment using laser photothermal interactions. It may also provide guidance for laser immunotherapy in cancer treatment, since the immunological responses are believed to be related to tissue temperature changes. (c) 2006 Society of Photo-Optical Instrumentation Engineers.