A Reduction and pH Dual-Sensitive Polymeric Vector for Long-Circulating and Tumor-Targeted siRNA Delivery
A Reduction and pH Dual-Sensitive Polymeric Vector for Long-Circulating and Tumor-Targeted siRNA Delivery
复制标题
用于长循环和肿瘤靶向 siRNA 递送的还原和 pH 双敏感聚合载体
DOI：
10.1002/adma.201403877
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发表时间：
2014-12-23
影响因子：
29.4
通讯作者：
Shuai, Xintao
中科院分区：
文献类型：
--
作者：
Li, Jingguo;Yu, Xingsu;Shuai, Xintao
描述了一种用于长循环和肿瘤靶向siRNA递送的新型还原和pH双重敏感的非病毒载体。纳米药物在血液的中性pH值下带负电荷，而在肿瘤组织的较低pH值下带正电荷（约100%）。6.8）。与二硫键的层间交联在血液循环期间稳定纳米药物，并允许在胞吞作用后快速释放细胞内siRNA。
A novel reduction and pH dual-sensitive nonviral vector for long-circulating and tumor-targeted siRNA delivery is described. The nanomedicine is negatively charged at neutral pH of bloodstream whereas it is positively charged at lower pH of tumor tissue (ca. 6.8). Interlayer crosslinking with disulfide bonds stabilizes the nanomedicine during blood circulation and allows quick intracellular siRNA release after endocytosis.