Motor Action of the Frontal Eye Field on the Eyes and Neck in the Monkey
Motor Action of the Frontal Eye Field on the Eyes and Neck in the Monkey
复制标题
猴子眼睛和颈部额叶眼区的运动动作
DOI：
10.1152/jn.00577.2017
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发表时间：
2018
影响因子：
2.5
通讯作者：
H.
中科院分区：
文献类型：
--
作者：
Izawa;Y. and Suzuki;H.
在额叶眼野（FEF）的焦点刺激诱发的眼球运动，往往伴随着颈部运动。实验进行了同时记录的两个动作在受过训练的猴子。我们用测力系统记录了头部受限条件下颈部的力。利用该系统，我们测量了沿着x轴、y轴和z轴的力以及绕z轴的扭矩。代表头部偏航旋转的z轴扭矩受到刺激的显著影响。我们发现，刺激产生两种类型的运动动作的眼睛和颈部。在第一种类型中，通过刺激FEF的内侧部分诱发反向颈部力，其中诱发具有大幅度的反向扫视眼球运动。当刺激强度增加时，以全或无的方式诱发扫视，而颈部力的幅度逐渐增加。在第二种类型中，通过刺激FEF的内侧和尾侧部分诱发反向颈部力，其中诱发同侧缓慢眼球运动。颈部力幅值的深度剖面与眼动的深度剖面在单个刺激轨迹上几乎平行。目前的结果表明，FEF参与控制的运动动作的颈部以及眼睛。与逆向扫视和逆向颈部运动相关的FEF区域可能有助于注视转移过程，而与同侧缓慢眼动和逆向颈部运动相关的FEF区域可能有助于视觉稳定过程。我们用测力系统记录了头部受限条件下颈部的力。利用这种方法，我们可以分析与前庭眼反射无关的缓慢眼球运动。我们发现，同向缓慢的眼球运动与逆向颈部力量相结合，这表明FEF可能是一个必然的来源，在自愿颈部运动的代偿性眼球运动的放电信号。
Focal stimulation in the frontal eye field (FEF) evoked eye movements that were often accompanied by neck movements. Experiments were performed with concurrent recording of both movements in trained monkeys. We recorded neck forces under a head-restrained condition with a force-measuring system. With the system, we measured forces along thex-,y-, andz-axes and torque about thez-axis. Torque about thez-axis that represented yaw rotation of the head was significantly affected by stimulation. We found that stimulation generated two types of motor actions of the eyes and neck. In the first type, contraversive neck forces were evoked by stimulation of the medial part of the FEF, where contraversive saccadic eye movements with large amplitudes were evoked. When the stimulus intensity was increased, saccades were evoked in an all-or-none manner, whereas the amplitude of neck forces increased gradually. In the second type, contraversive neck forces were evoked by stimulation of the medial and caudal part of the FEF, where ipsiversive slow eye movements were evoked. The depth profiles of amplitudes of neck forces were almost parallel to those of eye movements in individual stimulation tracks. The present results suggest that the FEF is involved in the control of motor actions of the neck as well as the eyes. The FEF area associated with contraversive saccades and contraversive neck movements may contribute to a gaze shift process, whereas that associated with ipsiversive slow eye movements and contraversive neck movements may contribute to a visual stabilization process.NEW & NOTEWORTHYFocal stimulation in the frontal eye field (FEF) evoked eye and neck movements. We recorded neck forces under a head-restrained condition with a force-measuring system. Taking advantage of this approach, we could analyze slow eye movements that were dissociated from the vestibuloocular reflex. We found ipsiversive slow eye movements in combination with contraversive neck forces, suggesting that the FEF may be a source of a corollary discharge signal for compensatory eye movements during voluntary neck movements.