Expression and role of Fc- and complement-receptors on human dendritic cells
Expression and role of Fc- and complement-receptors on human dendritic cells
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DOI：
10.1016/j.imlet.2005.11.023
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发表时间：
2006-04-15
影响因子：
4.4
通讯作者：
Erdei, A
中科院分区：
文献类型：
--
作者：
Bajtay, Z;Csomor, E;Erdei, A
树突状细胞（Dendritic cells，DC）是一种专职的抗原呈递细胞，它能摄取外周组织中的病原体/外来结构，然后迁移到次级淋巴器官，在那里它们通过激活幼稚T细胞启动适应性免疫应答。在抗原摄取的早期阶段，识别病原体相关分子模式的模式识别受体（包括甘露糖样受体、清道夫样受体和toll样受体）起重要作用。后来的受体结合调理抗原也参与吞噬作用。这些细胞膜分子包括各种Fc受体，识别不同同种型的抗体和各种补体受体，如CR 3。CR 4和钙网蛋白与CD 91的C1 q结合复合物。在这里，我们的目的是总结这些免疫复合物结合受体是如何参与DC成熟的启动，以及它们如何影响抗原呈递以及这些细胞的一些其他功能。(C)2006年由Elsevier B. V.出版
Dendritic cells (DCs) are professional antigen presenting cells, which take up pathogens/foreign structures in peripheral tissues, then migrate to secondary lymphoid organs where they initiate adaptive immune responses by activating naive T-cells. In the early phase of antigen uptake pattern recognition receptors (including mannose-, scavenger- and toll-like receptors) that recognize pathogen-associated molecular patterns play an important role. Later receptors binding opsonized antigen are also involved in phagocytosis. These cell membrane molecules include various Fc-receptors, recognizing different isotypes of antibodies and various complement-receptors, such as CR3. CR4 and the C1q-binding complex of calreticulin and CD91. Here we aim to summarize how these immunecomplex binding receptors are involved in the initiation of DC maturation, and how they influence antigen presentation as well as some additional functions of these cells. (C) 2006 Published by Elsevier B.V.