Experimental and numerical studies on standing surface acoustic wave microfluidics.
Experimental and numerical studies on standing surface acoustic wave microfluidics.
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DOI：
10.1039/c5lc00707k
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发表时间：
2016-02-07
期刊：
影响因子：
6.1
通讯作者：
Huang TJ
中科院分区：
文献类型：
--
作者：
Mao Z;Xie Y;Guo F;Ren L;Huang PH;Chen Y;Rufo J;Costanzo F;Huang TJ
驻波表面声波（SSAW）通常用于微流体中以操纵细胞和其他微/纳米颗粒。然而，除了简单的一维（1D）谐波驻波（HSW）模型外，仍然缺乏可以预测SSAW微流体中颗粒行为的实用模型。在此，我们建立了一个二维（2D）SSAW微流体模型的基础上的基本理论，在声电泳和我们以前的建模策略来预测声电泳的微粒在SSAW微流体。这种二维SSAW微流体模型考虑了边界振动，通道材料和通道尺寸对声传播的影响;作为实验验证，研究了连续流过由PDMS和硅制成的窄通道的微颗粒的声泳。实验观察到的微粒运动与数值预测相匹配，而1D HSW模型未能预测许多实验观察结果。特别地，一维HSW模型不能解释PDMS通道中侧壁上的颗粒聚集，这可以通过我们的二维SSAW微流体模型很好地解释。该模型可用于SSAW微流体器件的设计和优化。本文对声表面波微流控器件中微粒的声泳现象进行了数值模拟和实验研究。
Standing surface acoustic waves (SSAW) are commonly used in microfluidics to manipulate cells and other micro/nano particles. However, except for a simple one-dimensional (1D) harmonic standing waves (HSW) model, a practical model that can predict particle behaviour in SSAW microfluidics is still lacking. Herein, we established a two-dimensional (2D) SSAW microfluidic model based on the basic theory in acoustophoresis and our previous modelling strategy to predict the acoustophoresis of microparticles in SSAW microfluidics. This 2D SSAW microfluidic model considers the effects of boundary vibrations, channel materials, and channel dimensions on the acoustic propagation; as an experimental validation, the acoustophoresis of microparticles under continuous flow through narrow channels made of PDMS and silicon was studied. The experimentally observed motion of the microparticles matched well with the numerical predictions, while the 1D HSW model failed to predict many of the experimental observations. Particularly, the 1D HSW model cannot account for particle aggregation on the sidewall in PDMS channels, which is well explained by our 2D SSAW microfluidic model. Our model can be used for device design and optimization in SSAW microfluidics. We numerically and experimentally investigate the acoustophoresis of microparticles in standing surface acoustic wave microfluidic devices.