In vitro activities of six antifungal agents and their combinations against Chaetomium spp.
In vitro activities of six antifungal agents and their combinations against Chaetomium spp.
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DOI：
10.1099/jmm.0.001004
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发表时间：
2019-05
影响因子：
3
通讯作者：
Lingyue Sun;Z. Wan;Ruoyu Li;Jin Yu
中科院分区：
文献类型：
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作者：
Lingyue Sun;Z. Wan;Ruoyu Li;Jin Yu
目的评价6种抗真菌药物（阿替霉素B、伊曲康唑、伏立康唑、泊沙康唑、卡泊芬净和特比萘芬）对22株毛壳菌的体外抗菌活性，以及它们与阿替霉素B、伊曲康唑、伏立康唑和泊沙康唑的8对联合作用。方法：采用微量肉汤稀释法和棋盘法评价抗真菌药物单独和联合应用对毛壳菌的体外活性。结果两性霉素B和三唑类药物的几何平均值、MIC 50和MIC 90均低于卡泊芬净和特比萘芬。此外，所有药物配对均表现出不同程度的协同作用，其中卡泊芬净与伊曲康唑的相互作用占首位（86.36%）。结论卡泊芬净和特比萘芬与伊曲康唑、伏立康唑、泊沙康唑和阿替霉素B对毛壳菌有不同程度的协同作用。为临床治疗毛壳菌病提供参考。感染.
PURPOSE To assess in vitro activities of six antifungal agents (amphotericin B, itraconazole, voriconazole, posaconazole, caspofungin and terbinafine) and the combined effects of eight pairs of them (caspofungin or terbinafine with amphotericin B, itraconazole, voriconazole or posaconazole) against 22 isolates of Chaetomium spp. METHODOLOGY The broth microdilution method drafted by the Clinical and Laboratory Standards Institute and the checkerboard method were used in this study to evaluate in vitro activities of antifungal drugs both alone and in combination against Chaetomium spp. RESULTS Amphotericin B and triazoles exhibited lower geometric mean, MIC50 and MIC90 than caspofungin and terbinafine. Besides, all the paired drugs displayed varying degrees of synergism, with the interactions between caspofungin and itraconazole ranking first (86.36 %). CONCLUSION Our study illustrated varying degrees of synergism between caspofungin or terbinafine and itraconazole, voriconazole, posaconazole or amphotericin B towards Chaetomium spp., which could be a reference for the clinical treatment of Chaetomium spp. infections.